AMG 548
Modify Date: 2024-01-31 13:16:56
AMG 548 structure
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Common Name | AMG 548 | ||
|---|---|---|---|---|
| CAS Number | 864249-60-5 | Molecular Weight | 461.55800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H27N5O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of AMG 548AMG-548 is a potent, oral and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γand p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 inhibits Wnt signaling by direcly inhibing Casein kinase 1 isoforms δ and ε[2]. |
| Name | 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone |
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| Synonym | More Synonyms |
| Description | AMG-548 is a potent, oral and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γand p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 inhibits Wnt signaling by direcly inhibing Casein kinase 1 isoforms δ and ε[2]. |
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| Related Catalog | |
| Target |
p38α:0.5 nM (Ki) p38β:3.6 nM (Ki) CK1 |
| In Vivo | AMG-548 has rat F of 62% and dog F of 47%. The t1/2 is 4.6 hours in rats and 7.3 hours in dogs[1]. |
| References |
| Molecular Formula | C29H27N5O |
|---|---|
| Molecular Weight | 461.55800 |
| Exact Mass | 461.22200 |
| PSA | 85.83000 |
| LogP | 5.41770 |
| Hazard Codes | Xi |
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| AMG 548 |
| (S)-2-(2-amino-3-phenylpropylamino)-1-methyl-5-(2-naphthyl)-4-(4-pyridyl)pyrimidine-6-one |
| 2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-naphthalen-2-yl-6-pyridin-4-ylpyrimidin-4-one |