Urokinase

Modify Date: 2024-01-02 08:54:48

Urokinase Structure
Urokinase structure
Common Name Urokinase
CAS Number 9039-53-6 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C21H25BrN2O3 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Urokinase


Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research[1].

 Names

Name Urokinase
Synonym More Synonyms

 Urokinase Biological Activity

Description Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research[1].
Related Catalog
In Vitro Urokinase peptidolytic(uPA) 在非小细胞肺癌 (NSCLC) 中能够增加 uPAR 蛋白质和 mRNA 水平的表达[1]。
References

[1]. Nunzia Montuori, et al. Urokinase-mediated posttranscriptional regulation of urokinase-receptor expression in non small cell lung carcinoma. Int J Cancer. 2003 Jun 20;105(3):353-60  

 Chemical & Physical Properties

Molecular Formula C21H25BrN2O3
Appearance of Characters powder | white
Storage condition 2-8°C
Water Solubility Soluble in water. | Reconstitute in water at 100µg/ml

 Safety Information

Hazard Codes B
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS OB8900000

 Articles87

More Articles
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.

J. Immunol. 192(8) , 3847-57, (2014)

Hypoxia-inducible factor-1α (HIF-1α) is activated in hepatic stellate cells (HSCs) by hypoxia and regulates genes important for tissue repair. Whether HIF-1α is activated in HSCs after acute injury an...

Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor.

Am. J. Physiol. Endocrinol. Metab. 307(3) , E278-88, (2014)

Further development in research of bone regeneration is necessary to meet the clinical demand for bone reconstruction. Recently, we reported that plasminogen is crucial for bone repair through enhance...

Endocrine regulation of airway contractility is overlooked.

J. Endocrinol. 222(2) , R61-73, (2014)

Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated activation of the...

 Synonyms

urokinase, high mw (urine)
ec 3.4.99.26
urokinase, low mw (urine)
urokinase
urokinase upa 2-chain
urokinase, high molecular weight
urokinase 2-chain
MFCD00132566
urokinase (mixed)