Urokinase
Urokinase structure
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Common Name | Urokinase | ||
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| CAS Number | 9039-53-6 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H25BrN2O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.
J. Immunol. 192(8) , 3847-57, (2014) Hypoxia-inducible factor-1α (HIF-1α) is activated in hepatic stellate cells (HSCs) by hypoxia and regulates genes important for tissue repair. Whether HIF-1α is activated in HSCs after acute injury and contributes to liver regeneration, however, is not known.... |
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Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor.
Am. J. Physiol. Endocrinol. Metab. 307(3) , E278-88, (2014) Further development in research of bone regeneration is necessary to meet the clinical demand for bone reconstruction. Recently, we reported that plasminogen is crucial for bone repair through enhancement of vessel formation. However, the details of the role ... |
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Endocrine regulation of airway contractility is overlooked.
J. Endocrinol. 222(2) , R61-73, (2014) Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated activation of the smooth muscle surrounding the airways, as well as a propen... |
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Deregulated expression of urokinase and its inhibitor type 1 in prostate cancer cells: Role of epigenetic mechanisms
Exp. Mol. Pathol. 94(3) , 458-65, (2013) Plasminogen activator inhibitor-1 (PAI-1) and urokinase-type plasminogen activator (uPA) play a crucial role in cancer progression. In the present study we examined the regulation of PAI-1 and uPA expressions in normal prostate epithelial cells (PrEC) and the... |
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[A case of recurrent colon cancer developed thrombosis in superior mesenteric vein after chemotherapy].
Gan To Kagaku Ryoho. 40(5) , 659-61, (2013) A 48-year-old man was administered bevacizumab+FOLFOX for lymph node recurrence of colon cancer in the abdominal cavity, and developed serious thrombosis of the portal system after 6 courses of the chemotherapy. We discontinued it promptly and anticoagulant t... |
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Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.
Arterioscler. Thromb. Vasc. Biol. 35(1) , 155-62, (2015) Low-density lipoprotein receptor-related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to several vascular pathologies when deleted in vascular smooth muscle cells (SMCs). The purpose of this study was ... |
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Berberine Reverses Epithelial-to-Mesenchymal Transition and Inhibits Metastasis and Tumor-Induced Angiogenesis in Human Cervical Cancer Cells.
Mol. Pharmacol. 86(6) , 609-23, (2014) Metastasis is the most common cause of cancer-related death in patients, and epithelial-to-mesenchymal transition (EMT) is essential for cancer metastasis, which is a multistep complicated process that includes local invasion, intravasation, extravasation, an... |
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Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
Meth. Enzymol. 80 , 341, (1981)
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Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells.
Carcinogenesis 34(4) , 864-73, (2013) We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo. Loss of E-cadherin expression and induction of mesenchymal markers (e.g. vimentin) are bioc... |
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Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.
FASEB J. 27(11) , 4520-31, (2013) Urokinase-type plasminogen activator (uPA) activates plasminogen (Plg) through a major pericellular proteolytic system involved in cell migration and angiogenesis; however, the Plg receptor that participates in uPA-mediated Plg activation has not yet been ide... |