Gemfibrozil 1-O-β-glucuronide

Modify Date: 2024-01-03 06:56:50

Gemfibrozil 1-O-β-glucuronide structure	Common Name	Gemfibrozil 1-O-β-glucuronide
	CAS Number	91683-38-4	Molecular Weight	426.45800
	Density	1.32g/cm3	Boiling Point	611.2ºC at 760mmHg
	Molecular Formula	C₂₁H₃₀O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	208.4ºC

Use of Gemfibrozil 1-O-β-glucuronide

Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2].

Name	gemfibrozil 1-o--glucuronide
Synonym	More Synonyms

Description	Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
Target	CYP2C8:4.07 μM (IC50)
In Vitro	Gemfibrozil 1-O-β-Glucuronide significantly inhibits the OATP2 (OATP1B1)-mediated uptake of Cerivastatin (CER; HY-129458) with an IC50 of 24.3 μM[1]. Gemfibrozil 1-O-β-Glucuronide inhibits CYP2C8-mediated M1, M23 formation with IC50s of 5.38 μM, 4.30 μM, and has no effects for CYP2C8-mediated M3 formation[1]. Gemfibrozil 1-O-β-Glucuronide has an IC50 of 243 μM for the CYP3A4- mediated metabolism[1].
References	[1]. Shitara Y, et al. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2(OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36. [2]. Baer BR, et al. Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition. Chem Res Toxicol. 2009 Jul;22(7):1298-309.

Density	1.32g/cm3
Boiling Point	611.2ºC at 760mmHg
Molecular Formula	C₂₁H₃₀O₉
Molecular Weight	426.45800
Flash Point	208.4ºC
Exact Mass	426.18900
PSA	142.75000
LogP	0.92400
Index of Refraction	1.572

Gemfibrozilb-D-glucuronide

Gemfibrozil 1-O-b-Glucuronide

gemfibrozil 1-O-acylglucuronide

1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate] b-D-Glucopyranuroic Acid,Gemfibrozil Glucuronide

1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate]-D-Glucopyranuroic Acid

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: GEMFIBROZIL 1-O-?-GLUCURONIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

Gemfibrozil 1-O-β-glucuronide suppliers

Gemfibrozil 1-O-β-glucuronide price

Gemfibrozil 1-O-β-glucuronide

Use of Gemfibrozil 1-O-β-glucuronide

Names

Gemfibrozil 1-O-β-glucuronide Biological Activity

Chemical & Physical Properties

Synonyms