Name | gemfibrozil 1-o--glucuronide |
---|---|
Synonyms |
Gemfibrozilb-D-glucuronide
Gemfibrozil 1-O-b-Glucuronide gemfibrozil 1-O-acylglucuronide 1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate] b-D-Glucopyranuroic Acid,Gemfibrozil Glucuronide 1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate]-D-Glucopyranuroic Acid |
Description | Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2]. |
---|---|
Related Catalog | |
Target |
CYP2C8:4.07 μM (IC50) |
In Vitro | Gemfibrozil 1-O-β-Glucuronide significantly inhibits the OATP2 (OATP1B1)-mediated uptake of Cerivastatin (CER; HY-129458) with an IC50 of 24.3 μM[1]. Gemfibrozil 1-O-β-Glucuronide inhibits CYP2C8-mediated M1, M23 formation with IC50s of 5.38 μM, 4.30 μM, and has no effects for CYP2C8-mediated M3 formation[1]. Gemfibrozil 1-O-β-Glucuronide has an IC50 of 243 μM for the CYP3A4- mediated metabolism[1]. |
References |
Density | 1.32g/cm3 |
---|---|
Boiling Point | 611.2ºC at 760mmHg |
Molecular Formula | C21H30O9 |
Molecular Weight | 426.45800 |
Flash Point | 208.4ºC |
Exact Mass | 426.18900 |
PSA | 142.75000 |
LogP | 0.92400 |
Index of Refraction | 1.572 |