MPC 6827 hydrochloride

Modify Date: 2024-01-10 00:35:53

MPC 6827 hydrochloride structure	Common Name	MPC 6827 hydrochloride
	CAS Number	917369-31-4	Molecular Weight	315.79700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₈ClN₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MPC 6827 hydrochloride

Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types[1][2].

Name	N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride (1:1)

Description	Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	microtubule[1]
References	[1]. Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67(12):5865-71. [2]. Sirisoma N, et al. Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J Med Chem. 2009 Apr 23;52(8):2341-51.

Molecular Formula	C₁₇H₁₈ClN₃O
Molecular Weight	315.79700
Exact Mass	315.11400
PSA	38.25000
LogP	4.51670

MPC 6827 hydrochloride

Use of MPC 6827 hydrochloride

Names

MPC 6827 hydrochloride Biological Activity

Chemical & Physical Properties