PSB 0474

Modify Date: 2024-01-12 16:46:58

PSB 0474 structure	Common Name	PSB 0474
	CAS Number	917567-60-3	Molecular Weight	522.29
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₀N₂O₁₃P₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PSB 0474

PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].

Name	PSB 0474,3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphatedisodiumsalt
Synonym	More Synonyms

Description	PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Neurological Disease
Target	IC50: 70 nM (P2Y6)[1]
References	[1]. Ali El-Tayeb, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. [2]. Clara Quintas, et al. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014 Sep 3;11:141.

Molecular Formula	C₁₇H₂₀N₂O₁₃P₂
Molecular Weight	522.29
Exact Mass	566.00800
PSA	249.33000

3-phenacyl udp disodium salt

psb 0474

PSB 0474

Use of PSB 0474

Names

PSB 0474 Biological Activity

Chemical & Physical Properties

Synonyms