UHRF1 PHD inhibitor MLD4

Modify Date: 2025-08-25 15:48:57

UHRF1 PHD inhibitor MLD4 Structure
UHRF1 PHD inhibitor MLD4 structure
 Common Name UHRF1 PHD inhibitor MLD4
CAS Number 922067-76-3 Molecular Weight 416.522
Density N/A Boiling Point N/A
Molecular Formula C22H32N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of UHRF1 PHD inhibitor MLD4


UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.

 Names

Name UHRF1 PHD inhibitor MLD4

 UHRF1 PHD inhibitor MLD4 Biological Activity

Description UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
References 1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10.

 Chemical & Physical Properties

Molecular Formula C22H32N4O4
Molecular Weight 416.522
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