Sappanchalcone

Modify Date: 2024-01-02 15:19:18

Sappanchalcone Structure
Sappanchalcone structure
Common Name Sappanchalcone
CAS Number 94344-54-4 Molecular Weight 286.279
Density 1.4±0.1 g/cm3 Boiling Point 581.7±50.0 °C at 760 mmHg
Molecular Formula C16H14O5 Melting Point N/A
MSDS N/A Flash Point 221.0±23.6 °C

 Use of Sappanchalcone


Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].

 Names

Name sappanchalcone
Synonym More Synonyms

 Sappanchalcone Biological Activity

Description Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].
Related Catalog
In Vitro Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].
References

[1]. Seo HW, et al. Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells. Chem Biol Interact. 2020;327:109185.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 581.7±50.0 °C at 760 mmHg
Molecular Formula C16H14O5
Molecular Weight 286.279
Flash Point 221.0±23.6 °C
Exact Mass 286.084137
PSA 86.99000
LogP 2.51
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.684

 Safety Information

Hazard Codes Xi
HS Code 2914509090

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

(2E)-3-(3,4-Dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)-2-propen-1-one
2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)-, (E)-
2'-Methoxy-3,4,4'-trihydroxychalcone
3,4,4'-Trihydroxy-2'-methoxychalcone
sapphalcone
(E)-3-(3,4-dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)-, (2E)-
Sappan chalcone
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