Apararenone

Modify Date: 2025-08-25 11:29:12

Apararenone Structure
Apararenone structure
 Common Name Apararenone
CAS Number 945966-46-1 Molecular Weight 364.391
Density 1.4±0.1 g/cm3 Boiling Point 594.3±60.0 °C at 760 mmHg
Molecular Formula C17H17FN2O4S Melting Point N/A
MSDS N/A Flash Point 313.2±32.9 °C

 Use of Apararenone


Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

 Names

Name Apararenone
Synonym More Synonyms

 Apararenone Biological Activity

Description Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
Related Catalog
Target

Mineralocorticoid receptor[1]

In Vivo Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].
References

[1]. Kolkhof P, et al. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development. J Endocrinol. 2017 Jul;234(1):T125-T140.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 594.3±60.0 °C at 760 mmHg
Molecular Formula C17H17FN2O4S
Molecular Weight 364.391
Flash Point 313.2±32.9 °C
Exact Mass 364.089294
LogP 1.26
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.610
Storage condition 2-8℃

 Synonyms

Methanesulfonamide, N-[4-(4-fluorophenyl)-3,4-dihydro-2,2-dimethyl-3-oxo-2H-1,4-benzoxazin-7-yl]-
UNII:832663U2NB
832663U2NB
N-[4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methanesulfonamide
apararenone
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2-(3,4-dimethylphenyl)-4-{3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}isoquinolin-1(2H)-one
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2-(3,4-dimethylphenyl)-4-(3-(4-(methylthio)phenyl)-1,2,4-oxadiazol-5-yl)isoquinolin-1(2H)-one
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4-{3-[4-(benzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-2-(3,4-dimethylphenyl)isoquinolin-1(2H)-one
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2-(3,4-dimethylphenyl)-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}isoquinolin-1(2H)-one
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