945966-46-1

945966-46-1 structure

Name: Apararenone
Chemical Name: Apararenone
CAS Number: 945966-46-1
Molecular Formula: C₁₇H₁₇FN₂O₄S
Molecular Weight: 364.391
Catalog: Signaling Pathways Metabolic Enzyme/Protease Mineralocorticoid Receptor
Create Date: 2018-10-07 07:31:23
Modify Date: 2024-01-02 09:35:33
Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

Name	Apararenone
Synonyms	Methanesulfonamide, N-[4-(4-fluorophenyl)-3,4-dihydro-2,2-dimethyl-3-oxo-2H-1,4-benzoxazin-7-yl]- UNII:832663U2NB 832663U2NB N-[4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methanesulfonamide apararenone

Description	Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor Research Areas >> Metabolic Disease Research Areas >> Cardiovascular Disease
Target	Mineralocorticoid receptor[1]
In Vivo	Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].
References	[1]. Kolkhof P, et al. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development. J Endocrinol. 2017 Jul;234(1):T125-T140.