Org 25935

Modify Date: 2024-01-12 14:07:08

Org 25935 Structure
Org 25935 structure
Common Name Org 25935
CAS Number 949588-40-3 Molecular Weight 375.89
Density N/A Boiling Point N/A
Molecular Formula C21H26ClNO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Org 25935


Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse[1].

 Names

Name N-{[(1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydro-2-naphthalenyl] methyl}-N-methylglycine hydrochloride (1:1)
Synonym More Synonyms

 Org 25935 Biological Activity

Description Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse[1].
Related Catalog
Target

GlyT1:100 nM (IC50)

References

[1]. Molander A, et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats. Alcohol Alcohol. 2007;42(1):11-18.

 Chemical & Physical Properties

Molecular Formula C21H26ClNO3
Molecular Weight 375.89
Exact Mass 375.16000
PSA 49.77000
LogP 4.20790

 Synonyms

Org 25935
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