2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl

Modify Date: 2026-09-21 09:26:04

2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl Structure
2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl structure
 Common Name 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl
CAS Number 950-99-2 Molecular Weight 220.30700
Density 1.034g/cm3 Boiling Point 344.3ºC at 760 mmHg
Molecular Formula C14H20O2 Melting Point 89-91ºC(lit.)
MSDS N/A Flash Point 146.1ºC

 Use of 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl


2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol
Synonym More Synonyms

  Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].
Related Catalog
References

[1]. Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.034g/cm3
Boiling Point 344.3ºC at 760 mmHg
Melting Point 89-91ºC(lit.)
Molecular Formula C14H20O2
Molecular Weight 220.30700
Flash Point 146.1ºC
Exact Mass 220.14600
PSA 29.46000
LogP 3.42100
Index of Refraction 1.529
InChIKey SEBPXHSZHLFWRL-UHFFFAOYSA-N
SMILES Cc1c(C)c2c(c(C)c1O)CCC(C)(C)O2

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26-36
HS Code 2932999099

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Bioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antioxidant activity assessed as inhibition of TBARS production in ferrous salt/ascor...
Source: ChEMBL
Target: N/A
External Id: CHEMBL865718
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
Name: The concentration of compound required to inhibit generation of superoxide by 50 perc...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL794715
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
Name: LPO-lowering activity was estimated by the IC50 value of compound in rat liver micros...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL794714
Name: Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membr...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL834109
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
Name: Antimycobacterial activity against Mycobacterium bovis BCG Pasteur after 6 days by mi...
Source: ChEMBL
Target: Mycobacterium tuberculosis variant bovis BCG
External Id: CHEMBL1033536
Name: Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by m...
Source: ChEMBL
Target: Mycobacterium tuberculosis
External Id: CHEMBL1033537
Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
Total 13, Current Page 1 of 2
1
2

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

PMHCR
2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl
2,2,5,7,8-pentamethyl-6-hydroxy-chromane
MFCD00210347
Chromane C1
6-Hydroxy-2,2,5,7,8-pentamethylchroman
2,2,5,7,8-pentamethylchroman-6-ol
2,2,5,7,8-Pentamethyl-1-hydroxychroman
2,2,5,7,8-Pentamethyl-6-hydroxychroman
2,2,5,7,8-Pentamethyl-6-chromanol
Chroman C1

  | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: The English name of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol is 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol.
Q: What is the safety information for 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: Safety information for 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol: 26-36.
Q: What are the upstream materials of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: Related upstream materials(CAS) of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol: 700-13-0;556-82-1;1191-16-8;78-79-5;115-18-4;72863-21-9;79579-90-1.
Q: What is the boiling point of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: Boiling point of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol is 344.3ºC at 760 mmHg.
Q: What are the uses of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: Main uses of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol: 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].
Q: What English synonyms does 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol have?
A: English synonyms of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol: PMHCR, 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl, 2,2,5,7,8-pentamethyl-6-hydroxy-chromane, MFCD00210347, Chromane C1, 6-Hydroxy-2,2,5,7,8-pentamethylchroman, 2,2,5,7,8-pentamethylchroman-6-ol, 2,2,5,7,8-Pentamethyl-1-hydroxychroman, 2,2,5,7,8-Pentamethyl-6-hydroxychroman, 2,2,5,7,8-Pentamethyl-6-chromanol, Chroman C1.
Q: What is the molecular weight of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: Molecular weight of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol is 220.30700.
Q: What is the CAS number of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: CAS number of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol is 950-99-2.
Q: What are the downstream products of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: Related downstream products(CAS) of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol: 617-94-7;79579-90-1;56306-89-9;57721-81-0.
Q: What is the melting point of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol?
A: Melting point of 2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol is 89-91ºC(lit.).

 factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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Chemsrc provides CAS#:950-99-2 MSDS, density, melting point, boiling point, structure, etc. Its name is 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl>> amp version: 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl

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