2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl

Modify Date: 2025-09-15 04:49:06

2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl structure	Common Name	2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl
	CAS Number	950-99-2	Molecular Weight	220.30700
	Density	1.034g/cm3	Boiling Point	344.3ºC at 760 mmHg
	Molecular Formula	C₁₄H₂₀O₂	Melting Point	89-91ºC(lit.)
	MSDS	N/A	Flash Point	146.1ºC

Use of 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl

2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].

Name	2,2,5,7,8-pentamethyl-3,4-dihydrochromen-6-ol
Synonym	More Synonyms

Description	2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.

Density	1.034g/cm3
Boiling Point	344.3ºC at 760 mmHg
Melting Point	89-91ºC(lit.)
Molecular Formula	C₁₄H₂₀O₂
Molecular Weight	220.30700
Flash Point	146.1ºC
Exact Mass	220.14600
PSA	29.46000
LogP	3.42100
Index of Refraction	1.529
InChIKey	SEBPXHSZHLFWRL-UHFFFAOYSA-N
SMILES	Cc1c(C)c2c(c(C)c1O)CCC(C)(C)O2

MSDS(Chinese)

Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
HS Code	2932999099

Precursor 7
CAS#:700-13-0 2,3,5-Trimethyl... CAS#:556-82-1 3-Methyl-2-bute... CAS#:1191-16-8 Prenyl acetate CAS#:78-79-5 isoprene
CAS#:115-18-4 2-Methyl-3-bute... CAS#:72863-21-9 1-methyl-4-(2-m... CAS#:79579-90-1 2,2,5,7,8-penta...
DownStream 4
CAS#:617-94-7 α-Cumyl alcohol CAS#:79579-90-1 2,2,5,7,8-penta... CAS#:56306-89-9 2,2,5,7,8-penta... CAS#:57721-81-0 acetic acid,2,2...

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Antioxidant activity assessed as inhibition of TBARS production in ferrous salt/ascor...
Source: ChEMBL
Target: N/A
External Id: CHEMBL865718

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082

Name: The concentration of compound required to inhibit generation of superoxide by 50 perc...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL794715

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805

Name: LPO-lowering activity was estimated by the IC50 value of compound in rat liver micros...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL794714

Name: Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membr...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL834109

Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582

Name: Antimycobacterial activity against Mycobacterium bovis BCG Pasteur after 6 days by mi...
Source: ChEMBL
Target: Mycobacterium tuberculosis variant bovis BCG
External Id: CHEMBL1033536

Name: Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by m...
Source: ChEMBL
Target: Mycobacterium tuberculosis
External Id: CHEMBL1033537

Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149

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PMHCR

2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl

2,2,5,7,8-pentamethyl-6-hydroxy-chromane

MFCD00210347

Chromane C1

6-Hydroxy-2,2,5,7,8-pentamethylchroman

2,2,5,7,8-pentamethylchroman-6-ol

2,2,5,7,8-Pentamethyl-1-hydroxychroman

2,2,5,7,8-Pentamethyl-6-hydroxychroman

2,2,5,7,8-Pentamethyl-6-chromanol

Chroman C1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl

Use of 2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.