Ipragliflozin L-Proline

Modify Date: 2024-01-02 10:51:14

Ipragliflozin L-Proline structure	Common Name	Ipragliflozin L-Proline
	CAS Number	951382-34-6	Molecular Weight	519.58200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₀FNO₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ipragliflozin L-Proline

Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

Name	(2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol,(2S)-pyrrolidine-2-carboxylic acid
Synonym	More Synonyms

Description	Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT Research Areas >> Metabolic Disease
Target	IC50 value: 2.8 nM (SGLT2)[1][2].
In Vitro	Ipragliflozin (L-Proline) potently and selectively inhibits human, rat, and mouse SGLT2 at nanomolar ranges and exhibits stability against intestinal glucosidases[3].
In Vivo	Ipragliflozin (L-Proline) shows good pharmacokinetic properties following oral dosing, and dose-dependently increases urinary glucose excretion, which lasts for over 12 h in normal mice [3]. Oral administration of ipragliflozin increases urinary glucose excretion in a dose-dependent manner, an effect which is significant at doses of 0.3 mg/kg or higher and lasts over 12 h[4]. Single administration of ipragliflozin dose-dependently increases urinary glucose excretion, reduces blood glucose and plasma insulin levels, and improves glucose intolerance [5].
References	[1]. Imamura M, et al. Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Bioorg Med Chem. 2012 May 15;20(10):3263-79. [2]. Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701. [3]. Tahara A, et al. Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2012 Apr;385(4):423-36. [4]. Tahara A, et al. Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice. J Pharmacol Sci. 2012;120(1):36-44. [5]. Tahara A, et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol. 2013 Sep 5;715(1-3):246-55.

Molecular Formula	C₂₆H₃₀FNO₇S
Molecular Weight	519.58200
Exact Mass	519.17300
PSA	167.72000
LogP	2.29790
Storage condition	2-8℃

ASP-1941

Ipragliflozin L-proline

UNII-M6N3GK48A4

Ipragliflozin (L-Proline)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ipragliflozin L-Proline
Price: Click To Check
Purity: 90.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ipragliflozin L-Proline
Price: ￥1976.0/1g ￥786.0/250mg
Purity: 95.0%
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DC Chemicals Limited
China
Product Name: Ipragliflozin (L-Proline)
Price: $350.0/100mg $550.0/250mg $1100.0/1g
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Ipragliflozin L-Proline
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥1100/5 mg

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