Flunixin Meglumine

Modify Date: 2024-01-02 12:54:19

Flunixin Meglumine structure	Common Name	Flunixin Meglumine
	CAS Number	42461-84-7	Molecular Weight	491.458
	Density	1.403 g/cm3	Boiling Point	378.7ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₈F₃N₃O₇	Melting Point	136-138ºC
	MSDS	Chinese USA	Flash Point	182.8ºC
	Symbol	GHS07	Signal Word	Warning

Use of Flunixin Meglumine

Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Target: COXFlunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. Flunixin meglumine therapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs of inflammation and improved clinically graded depression when compared with these signs in saline solution-treated controls [1]. Flunixin meglumine was selective inhibitor of COX-1. Carprofen inhibited LPS-induction of iNOS. Carprofen and, to a lesser degree, flunixin meglumine had inhibitory effects on NFκB activation [2].

Name	flunixin meglumine
Synonym	More Synonyms

Description	Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Target: COXFlunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. Flunixin meglumine therapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs of inflammation and improved clinically graded depression when compared with these signs in saline solution-treated controls [1]. Flunixin meglumine was selective inhibitor of COX-1. Carprofen inhibited LPS-induction of iNOS. Carprofen and, to a lesser degree, flunixin meglumine had inhibitory effects on NFκB activation [2].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-2:0.4 nM (IC50) COX-1:17 nM (IC50)
References	[1]. Cheng Z, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66. [2]. Bryant, C.E., B.A. Farnfield, and H.J. Janicke, Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res, 2003. 64(2): p. 211-5.

Density	1.403 g/cm3
Boiling Point	378.7ºC at 760 mmHg
Melting Point	136-138ºC
Molecular Formula	C₂₁H₂₈F₃N₃O₇
Molecular Weight	491.458
Flash Point	182.8ºC
Exact Mass	491.187927
PSA	175.40000
LogP	0.95620
Storage condition	0-6°C
Water Solubility	H2O: freely soluble \| soluble

Flunixin Meglumine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4367000

CHEMICAL NAME :: D-Glucitol, 1-deoxy-1-(methylamino)-, 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3- pyridinecarboxylate (salt)

CAS REGISTRY NUMBER :: 42461-84-7

LAST UPDATED :: 199403

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H11-F3-N2-O2.C7-H17-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 39600 ug/kg/12D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 202,71,1993

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LZ4367000

Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses.

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Flunixin meglumine

MFCD01725419

2-{[2-Methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid - 1-deoxy-1-(methylamino)-D-glucitol (1:1)

EINECS 255-836-0

3-pyridinecarboxylic acid, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-, compd. with D-glucitol, 1-deoxy-1-(methylamino)- (1:1)

FLUNIXIN N-METHYLGLUCAMINE

2-[[2-Methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid meglumine salt Banamine

2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid - 1-deoxy-1-(methylamino)-D-glucitol (1:1)

Flunixin (meglumine)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Flunixin Meglumine
Price: ￥898.0/100mg ￥2688.0/500mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Flunixin Meglumine
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Flunixin meglumin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Flunixin meglumine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Flunixin Meglumine (300 mg)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Flunixin Meglumine

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