m-PEG3-phosphonic acid

Modify Date: 2024-03-03 11:54:06

m-PEG3-phosphonic acid Structure
m-PEG3-phosphonic acid structure
Common Name m-PEG3-phosphonic acid
CAS Number 96962-42-4 Molecular Weight 228.18000
Density 1.251±0.06 g/cm3(20 °C , 760mmHg) Boiling Point 382.9±50.0 °C (760 mmHg)
Molecular Formula C7H17O6P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of m-PEG3-phosphonic acid


m-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Phosphonic acid, P-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-
Synonym More Synonyms

 m-PEG3-phosphonic acid Biological Activity

Description m-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.251±0.06 g/cm3(20 °C , 760mmHg)
Boiling Point 382.9±50.0 °C (760 mmHg)
Molecular Formula C7H17O6P
Molecular Weight 228.18000
Exact Mass 228.07600
PSA 95.03000

 Synonyms

Phosphonic acid, [2-[2-(2-methoxyethoxy)ethoxy]ethyl]-