Benzenesulfonamide

Modify Date: 2026-06-30 18:43:01

Benzenesulfonamide structure	Common Name	Benzenesulfonamide
	CAS Number	98-10-2	Molecular Weight	157.19
	Density	1.3±0.1 g/cm3	Boiling Point	299.1±23.0 °C at 760 mmHg
	Molecular Formula	C₆H₇NO₂S	Melting Point	149-152 °C(lit.)
	MSDS	Chinese USA	Flash Point	134.7±22.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of Benzenesulfonamide

Benzenesulphonamide (compound 1) is a potent carbonic anhydrase inhibitor. Benzenesulphonamide shows CA II inhibitory activity[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Benzenesulfonamide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Benzenesulphonamide (compound 1) is a potent carbonic anhydrase inhibitor. Benzenesulphonamide shows CA II inhibitory activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	CA II[1]
References	[1]. Thakur A, et al. QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index. Bioorg Med Chem. 2004 Feb 15;12(4):789-93.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	299.1±23.0 °C at 760 mmHg
Melting Point	149-152 °C(lit.)
Molecular Formula	C₆H₇NO₂S
Molecular Weight	157.19
Flash Point	134.7±22.6 °C
Exact Mass	157.019745
PSA	68.54000
LogP	0.62
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.584
InChIKey	KHBQMWCZKVMBLN-UHFFFAOYSA-N
SMILES	NS(=O)(=O)c1ccccc1
Water Solubility	4.3 g/L (16 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Benzenesulfonamide MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9380000

CHEMICAL NAME :: Benzenesulfonamide

CAS REGISTRY NUMBER :: 98-10-2

BEILSTEIN REFERENCE NO. :: 1100566

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H7-N-O2-S

MOLECULAR WEIGHT :: 157.20

WISWESSER LINE NOTATION :: ZSWR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 991 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1073,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 19(12),47,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,548,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(6),19,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(6),19,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5280 mg/kg/30D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),88,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12180 mg/kg/9W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(6),19,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 636 mg/kg/30W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(6),19,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0266 No. of Facilities: 126 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 2957 (estimated) No. of Female Employees: 1600 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DA9380000
HS Code	29350090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:98-09-9 chlorophenylsulfone CAS#:5339-67-3 N-Ethyl benzene... CAS#:16066-31-2 benzenesulfinamide CAS#:938-10-3 N-diazobenzenes...
CAS#:2512-24-5 Benzenesulfonam... CAS#:5339-69-5 N-Isopropylbenz... CAS#:129716-35-4 N-cyclopropyl b... CAS#:117824-61-0 N-(3-Phenylprop...
CAS#:5183-78-8 Benzenesulfonam... CAS#:1709-50-8 Benzenesulfonam...
DownStream 10
CAS#:107786-78-7 cyclopentyl N-[... CAS#:10504-97-9 N-[(4-chlorophe... CAS#:837-18-3 Benzenesulfonam... CAS#:108223-53-6 Benzenesulfonam...
CAS#:111711-98-9 [1-(benzenesulf... CAS#:107920-79-6 Methyl 4-(pheny... CAS#:104997-09-3 N-(3-aminopheny... CAS#:104667-72-3 Benzenesulfonam...
CAS#:1056-25-3 N-(triphenyl-λ5... CAS#:4392-37-4 N-[Amino(imino)...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Efficient tandem solid-phase extraction and liquid chromatography-triple quadrupole mass spectrometry method to determine polar benzotriazole, benzothiazole and benzenesulfonamide contaminants in environmental water samples.

J. Chromatogr. A. 1309 , 22-32, (2013)

An analytical method has been developed that allows the simultaneous determination of five benzotriazole (BTRs), four benzothiazole (BTs) and five benzenesulfonamide (BSAs) derivates. The method is ba...

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.

J. Clin. Invest. 124(6) , 2683-95, (2014)

In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of ...

Amorphous drug dispersions with mono- and diacyl lecithin: On molecular categorization of their feasibility and UV dissolution imaging.

Int. J. Pharm. 491 , 218-30, (2015)

There is a growing interest in drug-phospholipid complexes and similar formulations that are mostly solid dispersions with high drug load. This study aims to explore the feasibility of such phospholip...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Binding affinity against human carbonic anhydrase (hCA).
Source: ChEMBL
Target: Carbonic anhydrase 3
External Id: CHEMBL662691

Name: Inhibition of human recombinant Lp-PLA2 using PED6 as substrate preincubated for 30 m...
Source: ChEMBL
Target: Platelet-activating factor acetylhydrolase
External Id: CHEMBL3821821

Name: Diuretic activity was determined
Source: ChEMBL
Target: N/A
External Id: CHEMBL827330

Name: Partition coefficient (logP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL633738

Name: CHCl3-water partition coefficient, log P of the compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL3256049

Name: Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substr...
Source: ChEMBL
Target: Glutaminyl-peptide cyclotransferase
External Id: CHEMBL5149905

Name: Octanol-water partition coefficient, log P of the compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL3256050

Name: Partition coefficient (logP) (dodecane)
Source: ChEMBL
Target: N/A
External Id: CHEMBL637347

Name: Partition coefficient (logP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL637348

Name: Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assa...
Source: ChEMBL
Target: Carbonic anhydrase 1
External Id: CHEMBL2340479

Total 53, Current Page 1 of 6

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Benzosulfonamide

Benzosuifqnamide

BENZENESULPHOAMIDE

Benzene sulfonamtde

Benzenesulfonamide

mandb7973

BSA

EINECS 202-637-1

MFCD00007930

benzolsulfonamide

benzsulfamide

phenyl sulfonamide

ZSWR

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of Benzenesulfonamide?

A: Molecular formula of Benzenesulfonamide is C6H7NO2S.

Q: What is the English name of Benzenesulfonamide?

A: The English name of Benzenesulfonamide is Benzenesulfonamide.

Q: What are the upstream materials of Benzenesulfonamide?

A: Related upstream materials(CAS) of Benzenesulfonamide: 98-09-9;5339-67-3;16066-31-2;938-10-3;2512-24-5;5339-69-5;129716-35-4;117824-61-0;5183-78-8;1709-50-8.

Q: What is the molecular weight of Benzenesulfonamide?

A: Molecular weight of Benzenesulfonamide is 157.19.

Q: What is the CAS number of Benzenesulfonamide?

A: CAS number of Benzenesulfonamide is 98-10-2.

Q: What is the safety information for Benzenesulfonamide?

A: Safety information for Benzenesulfonamide: S36.

Q: What is the LogP of Benzenesulfonamide?

A: LogP of Benzenesulfonamide is 0.62.

Q: What is the InChIKey of Benzenesulfonamide?

A: InChIKey of Benzenesulfonamide is KHBQMWCZKVMBLN-UHFFFAOYSA-N.

Q: What is the polar surface area (PSA) of Benzenesulfonamide?

A: Polar surface area (PSA) of Benzenesulfonamide is 68.54000.

Q: What are the downstream products of Benzenesulfonamide?

A: Related downstream products(CAS) of Benzenesulfonamide: 107786-78-7;10504-97-9;837-18-3;108223-53-6;111711-98-9;107920-79-6;104997-09-3;104667-72-3;1056-25-3;4392-37-4.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzenesulfonamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Benzenesulfonamide
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Benzenesulfonamide suppliers

Price: ￥500/100 mg

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Benzenesulfonamide

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