Brompheniramine Maleate
Brompheniramine Maleate structure
|
Common Name | Brompheniramine Maleate | ||
|---|---|---|---|---|
| CAS Number | 980-71-2 | Molecular Weight | 435.312 | |
| Density | N/A | Boiling Point | 403ºC at 760 mmHg | |
| Molecular Formula | C20H23BrN2O4 | Melting Point | 134-135ºC | |
| MSDS | N/A | Flash Point | 48.2 °F | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of Brompheniramine MaleateBrompheniramine maleate is a histamine H1 receptors antagonist.Target: Histamine H1 ReceptorBrompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Brompheniramine had a long half-life and large volume of distribution in normal adults. It also had a prolonged antihistaminic effect in the skin as evidenced by suppression of the wheal and flare response to histamine and by suppression of pruritus [1, 2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | brompheniramine maleate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Brompheniramine maleate is a histamine H1 receptors antagonist.Target: Histamine H1 ReceptorBrompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Brompheniramine had a long half-life and large volume of distribution in normal adults. It also had a prolonged antihistaminic effect in the skin as evidenced by suppression of the wheal and flare response to histamine and by suppression of pruritus [1, 2]. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 403ºC at 760 mmHg |
|---|---|
| Melting Point | 134-135ºC |
| Molecular Formula | C20H23BrN2O4 |
| Molecular Weight | 435.312 |
| Exact Mass | 434.084106 |
| PSA | 90.73000 |
| LogP | 3.63950 |
| InChIKey | SRGKFVAASLQVBO-BTJKTKAUSA-N |
| SMILES | CN(C)CCC(c1ccc(Br)cc1)c1ccccn1.O=C(O)C=CC(=O)O |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | Xi |
| Risk Phrases | R22 |
| Safety Phrases | S36 |
| RIDADR | UN 3249 |
| WGK Germany | 3 |
| RTECS | US4025000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2934999090 |
| Flash Point(F) | 48.2 °F |
| Flash Point(C) | 9 °C |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Discovery of syn-/anti-cocaine-N-oxide diastereomers in unwashed postmortem hair via LC-MS-MS.
J. Anal. Toxicol. 38(6) , 360-7, (2014) The discovery of two cocaine-N-oxide (CNO) diastereomers, syn- and anti-CNO, is reported for the first time. Prior to this study, only one structural form of CNO was known to exist and has not been an... |
|
|
H1-antihistamines and oxidative burst of professional phagocytes.
Neuro Endocrinol. Lett. 30 Suppl 1 , 133-6, (2009) We analysed and compared the effect of five H1-antihistamines on stimulated oxidative burst at extra- and intracellular level of isolated and stimulated human polymorphonuclear leukocytes.Oxidative bu... |
|
|
Pheniramines and oxidative burst of blood phagocytes during ischaemia/reperfusion.
Inflamm. Res. 58 Suppl 1 , 66-7, (2009)
|
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
|
|
Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity
|
|
Name: Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: GDH-TPI_INH_ABS_1536_1X%INH CSRUN
|
|
Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (±)-2-[p-Bromo-a-(2-dimethylaminoethyl)benzyl]pyridine Maleate |
| D-Brompheniramine |
| dl-Bromopheniramine Maleate |
| Brompheniramine Maleate |
| (±)-Brompheniramine maleate |
| 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1) |
| Brompheniramine d |
| 3-(4-Bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1) |
| (+/-)-1-(4-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane |
| 2-pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) |
| Ilvin Maleate |
| (RS)-brompheniramine |
| MFCD00057367 |
| EINECS 213-562-9 |
| PARABROMODYLAMINE MALEATE |
| brompheniramine hydrogen maleate |
| 2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) |
| acide (2Z)-but-2-ènedioïque - 3-(4-bromophényl)-N,N-diméthyl-3-pyridin-2-ylpropan-1-amine (1:1) |
| 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate |
| (2Z)-But-2-endisäure--3-(4-bromphenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amin(1:1) |
| brompheniramine (maleate) |
| N-(3-THIOXO-3H-1,2,4-DITHIAZOL-5-YL)-2-THIOPHENECARBOXAMIDE |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of brompheniramine maleate? |
| A: Melting point of brompheniramine maleate is 134-135ºC. |
| Q: What is the CAS number of brompheniramine maleate? |
| A: CAS number of brompheniramine maleate is 980-71-2. |
| Q: What is the boiling point of brompheniramine maleate? |
| A: Boiling point of brompheniramine maleate is 403ºC at 760 mmHg. |
| Q: What is the SMILES notation of brompheniramine maleate? |
| A: SMILES notation of brompheniramine maleate is CN(C)CCC(c1ccc(Br)cc1)c1ccccn1.O=C(O)C=CC(=O)O. |
| Q: What is the English name of brompheniramine maleate? |
| A: The English name of brompheniramine maleate is brompheniramine maleate. |
| Q: What is the polar surface area (PSA) of brompheniramine maleate? |
| A: Polar surface area (PSA) of brompheniramine maleate is 90.73000. |
| Q: What is the safety information for brompheniramine maleate? |
| A: Safety information for brompheniramine maleate: S36. |
| Q: What is the InChIKey of brompheniramine maleate? |
| A: InChIKey of brompheniramine maleate is SRGKFVAASLQVBO-BTJKTKAUSA-N. |
| Q: What is the molecular formula of brompheniramine maleate? |
| A: Molecular formula of brompheniramine maleate is C20H23BrN2O4. |
| Q: What is the molecular weight of brompheniramine maleate? |
| A: Molecular weight of brompheniramine maleate is 435.312. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |