1,2-Dichloro-4-nitrobenzene

Modify Date: 2024-01-02 20:07:10

1,2-Dichloro-4-nitrobenzene structure	Common Name	1,2-Dichloro-4-nitrobenzene
	CAS Number	99-54-7	Molecular Weight	191.999
	Density	1.5±0.1 g/cm3	Boiling Point	255.5±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₃Cl₂NO₂	Melting Point	39-41 °C(lit.)
	MSDS	Chinese USA	Flash Point	123.9±0.0 °C
	Symbol	GHS07	Signal Word	Warning

Name	1,2-Dichloro-4-nitrobenzene
Synonym	More Synonyms

Density	1.5±0.1 g/cm3
Boiling Point	255.5±0.0 °C at 760 mmHg
Melting Point	39-41 °C(lit.)
Molecular Formula	C₆H₃Cl₂NO₂
Molecular Weight	191.999
Flash Point	123.9±0.0 °C
Exact Mass	190.954086
PSA	45.82000
LogP	3.16
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.596
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility	151 mg/L (20 ºC)
Freezing Point	30~31℃

1,2-Dichloro-4-nitrobenzene MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ5250000

CHEMICAL NAME :: Benzene, 1,2-dichloro-4-nitro-

CAS REGISTRY NUMBER :: 99-54-7

BEILSTEIN REFERENCE NO. :: 1818163

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C6-H3-Cl2-N-O2

MOLECULAR WEIGHT :: 192.00

WISWESSER LINE NOTATION :: WNR CG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 953 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1384 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/m3/4H/17W-I

TOXIC EFFECTS :: Blood - thrombocytopenia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/m3/4H/21D-I

TOXIC EFFECTS :: Blood - eosinophilia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 200 ppm

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,677,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H317-H319
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R22;R36;R51/53
Safety Phrases	S26-S36/37-S61-S39
RIDADR	2811
WGK Germany	3
RTECS	CZ5250000
Packaging Group	III
Hazard Class	9
HS Code	29049085

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HS Code	2904909090
Summary	HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Short-term black tea intake modulates the excretion of urinary mutagens in rats treated with 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ): role of CYP1A2 upregulation.

Arch. Toxicol. 78(8) , 477-82, (2004)

Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single...

Low glutathione S-transferase dogs.

Arch. Toxicol. 78(4) , 218-25, (2004)

Liver and kidney glutathione S-transferase (GST) activities to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activities) were measured in 280 dogs from five different breeders, and signific...

Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster.

J. Insect Sci. 12 , 107, (2012)

Glutathione transferases (GSTs) are a family of multifunctional enzymes involved in xenobiotic biotransformation, drug metabolism, and protection against oxidative damage. The p38b mitogen-activated p...

3,4-Dichloronitrobenzene

MFCD00007207

Benzene, 1,2-dichloro-4-nitro-

1,2-Dichloro-4-nitrobenzene

EINECS 202-764-2