BTZO 1
Modify Date: 2024-08-30 04:04:14
BTZO 1 structure
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Common Name | BTZO 1 | ||
|---|---|---|---|---|
| CAS Number | 99420-15-2 | Molecular Weight | 240.28000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H8N2OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BTZO 1BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1]. |
| Name | 2-pyridin-2-yl-1,3-benzothiazin-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd:68.6 nM (Macrophage migration inhibitory factor)[1] |
| In Vitro | BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM[1]. BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes[1]. Cell Viability Assay[1] Cell Line: Primary Neonatal Rat Cardiomyocytes Concentration: 0-330 nM Incubation Time: 24 hours Result: Suppressed serum deprivation or DOX-induced cell death. |
| References |
| Molecular Formula | C13H8N2OS |
|---|---|
| Molecular Weight | 240.28000 |
| Exact Mass | 240.03600 |
| PSA | 71.09000 |
| LogP | 2.71850 |
|
~44%
BTZO 1 CAS#:99420-15-2 |
| Literature: Takeda Pharmaceutical Company Limited Patent: EP1500402 A1, 2005 ; Location in patent: Page 12 ; |
|
~%
BTZO 1 CAS#:99420-15-2 |
| Literature: Conti; Leandri Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1957 , vol. 15, p. 37 |
|
~43%
BTZO 1 CAS#:99420-15-2 |
| Literature: Kimura, Harihide; Tanida, Seiichi; Kaneko, Tatsuhiko Patent: US2003/186971 A1, 2003 ; |
| BTZO-1 |
| 2-pyridin-2-yl-4H-1,3-benzothiazin-4-one |