99420-15-2

99420-15-2 structure

Name: BTZO 1
Chemical Name: 2-pyridin-2-yl-1,3-benzothiazin-4-one
CAS Number: 99420-15-2
Molecular Formula: C₁₃H₈N₂OS
Molecular Weight: 240.28000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-11-18 20:54:16
Modify Date: 2024-08-30 04:04:14
BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1].

Name	2-pyridin-2-yl-1,3-benzothiazin-4-one
Synonyms	BTZO-1 2-pyridin-2-yl-4H-1,3-benzothiazin-4-one

Description	BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease
Target	Kd:68.6 nM (Macrophage migration inhibitory factor)[1]
In Vitro	BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM[1]. BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes[1]. Cell Viability Assay[1] Cell Line: Primary Neonatal Rat Cardiomyocytes Concentration: 0-330 nM Incubation Time: 24 hours Result: Suppressed serum deprivation or DOX-induced cell death.
References	[1]. Kimura H, et al. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.Chem Biol. 2010 Dec 22;17(12):1282-94.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

100-70-9

4892-02-8

~44%

99420-15-2

Literature: Takeda Pharmaceutical Company Limited Patent: EP1500402 A1, 2005 ; Location in patent: Page 12 ;

100-70-9

147-93-3

99420-15-2

Literature: Conti; Leandri Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1957 , vol. 15, p. 37

100-70-9

17999-25-6

~43%

99420-15-2

Literature: Kimura, Harihide; Tanida, Seiichi; Kaneko, Tatsuhiko Patent: US2003/186971 A1, 2003 ;