Abicipar pegol

Modify Date: 2024-02-19 18:48:44

Abicipar pegol structure	Common Name	Abicipar pegol
	CAS Number	1327278-94-3	Molecular Weight	N/A
	Density	N/A	Boiling Point	N/A
	Molecular Formula	N/A	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Abicipar pegol

Abicipar pegol (AGN-150998, MP0112) is an anti-VEGF DARPin molecule, a novel class of small proteins containing ankyrin repeat domains engineered to bind with high specificity and affinity to target proteins. Abicipar pegol effectively inhibits angiogenesis and vascular permeability and is used in the study of diseases related to ocular inflammation by intravitreal injection, reducing mean retinal thickness and leakage area[1][2].

Name	Abicipar pegol

Description	Abicipar pegol (AGN-150998, MP0112) is an anti-VEGF DARPin molecule, a novel class of small proteins containing ankyrin repeat domains engineered to bind with high specificity and affinity to target proteins. Abicipar pegol effectively inhibits angiogenesis and vascular permeability and is used in the study of diseases related to ocular inflammation by intravitreal injection, reducing mean retinal thickness and leakage area[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
References	[1]. Gerard A Rodrigues, et al. Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5836-5846. [2]. Sepehr Bahadorani, et al. Recent advances in the management and understanding of macular degeneration. F1000Res. 2017 Apr 20;6:519.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

References

[1]. Gerard A Rodrigues, et al. Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5836-5846.

[2]. Sepehr Bahadorani, et al. Recent advances in the management and understanding of macular degeneration. F1000Res. 2017 Apr 20;6:519.

No Any Chemical & Physical Properties

Abicipar pegol

Use of Abicipar pegol

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Abicipar pegol Biological Activity

Chemical & Physical Properties