eIF4A3-IN-12

Modify Date: 2024-04-06 22:40:43

eIF4A3-IN-12 structure	Common Name	eIF4A3-IN-12
	CAS Number	1402931-76-3	Molecular Weight	496.94
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₅ClO₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of eIF4A3-IN-12

eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].

Name	eIF4A3-IN-12

Description	eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.

Molecular Formula	C₂₇H₂₅ClO₇
Molecular Weight	496.94

eIF4A3-IN-12

Use of eIF4A3-IN-12

Names

eIF4A3-IN-12 Biological Activity

Chemical & Physical Properties