Integrin Antagonist 1 (hydrochloride)
Modify Date: 2024-01-03 12:23:52
Integrin Antagonist 1 (hydrochloride) structure
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Common Name | Integrin Antagonist 1 (hydrochloride) | ||
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| CAS Number | 1629249-40-6 | Molecular Weight | 524.097 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H37N5O2.xHCl | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Integrin Antagonist 1 (hydrochloride)GSK 3008348 (hydrochloride) is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7). |
| Name | (3S)-3-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl]-4-{(3R)-3-[2-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-1-pyrrolidinyl}butanoic acid hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | GSK 3008348 (hydrochloride) is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7). |
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| Related Catalog | |
| Target |
pIC50 value: 8.4 (αvβ6)[1]. |
| References |
| Molecular Formula | C29H37N5O2.xHCl |
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| Molecular Weight | 524.097 |
| Exact Mass | 523.271423 |
| (3S)-3-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl]-4-{(3R)-3-[2-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-1-pyrrolidinyl}butanoic acid hydrochloride (1:1) |
| 1-Pyrrolidinebutanoic acid, β-[3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-3-[2-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-, (βS,3R)-, hydrochloride (1:1) |
| Integrin Antagonist 1 (hydrochloride) |