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3-吡啶甲醇

3-吡啶甲醇用途

3-吡啶甲醇(烟碱醇),一种吡啶衍生物,是一种降胆固醇剂[1][2]。

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3-吡啶甲醇名称

[ CAS 号 ]:
100-55-0

[ 中文名 ]:
3-吡啶甲醇

[ 英文名 ]:
Nicotinyl alcohol

[中文别名 ]:

3-羟甲基吡啶

[英文别名 ]:

(Pyridin-3-yl)methanol
3-Pyridylmethanol
pyridylcarbinol
pyridin-3-ylmethanol
3-Pyridinylmethanol
b-Pyridinecarbinol
3-PYRIDINYLCARBINOL
3-hydroxymethylpyridine
β-Pyridinecarbinol
3-Pyridinemethanol

3-吡啶甲醇生物活性

[ 描述 ]:

3-吡啶甲醇(烟碱醇),一种吡啶衍生物,是一种降胆固醇剂[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Heiberg A. Nikotinyl-alkohol som kolesterolsenkende medikament [Nicotinyl alcohol as a cholesterol-lowering agent]. Nord Med. 1969;81(22):698-700.

[2]. Gargaun S, et al. A novel method aimed at counteracting the side effects caused by prostaglandin e2 deficiency during non-steroidal anti-inflammatory drug therapy. Antiinflamm Antiallergy Agents Med Chem. 2014;13(2):121-127.

3-吡啶甲醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
266.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-7 °C

[ 分子式 ]:
C₆H₇NO

[ 分子量 ]:
109.126

[ 闪点 ]:
97.5±20.4 °C

[ 精确质量 ]:
109.052765

[ PSA ]:
33.12000

[ LogP ]:
-0.46

[ 外观性状 ]:
透明淡黄色至黄色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
soluble

3-吡啶甲醇MSDS

3-吡啶甲醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT4690000

CHEMICAL NAME :: 3-Pyridinemethanol

CAS REGISTRY NUMBER :: 100-55-0

BEILSTEIN REFERENCE NO. :: 0107851

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H7-N-O

MOLECULAR WEIGHT :: 109.14

WISWESSER LINE NOTATION :: T6NJ C1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 11,242,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 22,483,1962

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3-吡啶甲醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UT4690000

[ 海关编码 ]:
29333999

3-吡啶甲醇合成路线

3-吡啶甲醇上下游产品

3-吡啶甲醇上游产品

3-吡啶甲醇下游产品

3-吡啶甲醇制备

由吡啶为原料制得或用相应的吡啶甲醛还原，或由相应的吡啶羧酸酯催化氢化制得。

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3-吡啶甲醇海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-吡啶甲醇文献

Inhibitory effects of niacin and its analogues on induction of ornithine decarboxylase activity by diethylnitrosamine in rat liver.

Biochem. Pharmacol. 36(18) , 3015-9, (1987)

Pharmacological doses of niacin and its analogues were given intraperitoneally to rats with and without coadministration of a hepatocarcinogenic dose of diethylnitrosamine (DEN), and their effects on ...

The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine.

Eur. J. Med. Chem. 45(1) , 134-41, (2010)

Despite some initial research that reported a lack of activity of trans geometry, complexes with general formula trans-[PtCl2(L)(L')] exhibit an important cytotoxic activity in cisplatin-sensitive and...

Oxidation of alcohols using a manganese (II) complex based on a pentakis benzimidazole amide ligand.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 74(2) , 536-43, (2009)

A pentakis benzimidazole based penta-amide ligand diethylenetriamine-N,N,N',N',N''-pentakis(2-methyl benzimidazolyl)penta-amide [GBDTPA] has been synthesized and utilized to prepare Mn (II) complexes ...

更多文献

3-吡啶甲醇

3-吡啶甲醇用途

3-吡啶甲醇名称

3-吡啶甲醇生物活性

3-吡啶甲醇物理化学性质

3-吡啶甲醇MSDS

详细MSDS(安全技术说明书)

3-吡啶甲醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

3-吡啶甲醇安全信息

3-吡啶甲醇合成路线

详细合成路线

3-吡啶甲醇上下游产品

3-吡啶甲醇上游产品

3-吡啶甲醇下游产品

3-吡啶甲醇制备

3-吡啶甲醇海关

3-吡啶甲醇文献

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