三氯苯达唑亚砜

三氯苯达唑亚砜用途

Triclabendazole sulfoxide (TCBZ-SO) 是 Triclabendazole 的主要血浆代谢产物,具有抗寄生虫作用。Triclabendazole sulfoxide 可以抑制膜转运蛋白 ABCG2/BCRP 的活性。

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三氯苯达唑亚砜名称

[ CAS 号 ]:
100648-13-3

[ 中文名 ]:
三氯苯咪唑亚砜

[ 英文名 ]:
Triclabendazole sulfoxide

[中文别名 ]:

三氯苯达唑亚砜

[英文别名 ]:

Tcbz-SX
Triclabendazole sulfoxide
triclabendazole sulphoxide

三氯苯达唑亚砜生物活性

[ 描述 ]:

Triclabendazole sulfoxide (TCBZ-SO) 是 Triclabendazole 的主要血浆代谢产物,具有抗寄生虫作用。Triclabendazole sulfoxide 可以抑制膜转运蛋白 ABCG2/BCRP 的活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 跨膜转运 >> BCRP

[参考文献]

[1]. Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56(7):3535-43.

[2]. Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92(3):205-10.

三氯苯达唑亚砜物理化学性质

[ 密度 ]:
1.69

[ 沸点 ]:
547.6ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₉Cl₃N₂O₂S

[ 分子量 ]:
375.65700

[ 闪点 ]:
285ºC

[ 精确质量 ]:
373.94500

[ PSA ]:
74.19000

[ LogP ]:
5.91850

[ 蒸汽压 ]:
4.81E-12mmHg at 25°C

[ 折射率 ]:
1.749

[ 储存条件 ]:
2-8°C

三氯苯达唑亚砜安全信息

[ 危害声明 ]:
H413

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

三氯苯达唑亚砜合成路线

详细合成路线

三氯苯达唑亚砜上下游产品

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三氯苯达唑亚砜文献

Fasciola hepatica: disruption of the vitelline cells in vitro by the sulphoxide metabolite of triclabendazole.

Parasitol. Res. 82(4) , 333-9, (1996)

The effects of the active sulphoxide metabolite of the fasciolicide triclabendazole (Fasinex, Ciba-Geigy) on the vitelline cells of Fasciola hepatica were determined in vitro by transmission electron ...

Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep.

Exp. Parasitol. 136 , 14-9, (2014)

The flukicidal compound triclabendazole (TCBZ) has a complex metabolic pattern that includes the systemic presence of its sulphoxide (TCBZ.SO) and sulphone (TCBZ.SO2) metabolites, usually recovered fr...

Fasciola gigantica: tegumental surface alterations following treatment in vitro with the sulphoxide metabolite of triclabendazole.

Parasitol. Res. 88(4) , 315-25, (2002)

The effect of the active sulphoxide metabolite of the fasciolicide triclabendazole on the surface morphology of the tropical liver fluke, Fasciola gigantica, was determined in vitro by scanning electr...

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