三氯苯达唑亚砜

更新时间：2024-01-04 12:22:10

三氯苯达唑亚砜结构式	常用名	三氯苯达唑亚砜	英文名	Triclabendazole sulfoxide
	CAS号	100648-13-3	分子量	375.65700
	密度	1.69	沸点	547.6ºC at 760 mmHg
	分子式	C₁₄H₉Cl₃N₂O₂S	熔点	N/A
	MSDS	中文版美版	闪点	285ºC

三氯苯达唑亚砜用途

Triclabendazole sulfoxide (TCBZ-SO) 是 Triclabendazole 的主要血浆代谢产物,具有抗寄生虫作用。Triclabendazole sulfoxide 可以抑制膜转运蛋白 ABCG2/BCRP 的活性。

中文名	三氯苯咪唑亚砜
英文名	6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole
中文别名	三氯苯达唑亚砜
英文别名	更多

描述	Triclabendazole sulfoxide (TCBZ-SO) 是 Triclabendazole 的主要血浆代谢产物,具有抗寄生虫作用。Triclabendazole sulfoxide 可以抑制膜转运蛋白 ABCG2/BCRP 的活性。
相关类别	研究领域 >> 感染信号通路 >> 跨膜转运 >> BCRP
参考文献	[1]. Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56(7):3535-43. [2]. Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92(3):205-10.

描述

Triclabendazole sulfoxide (TCBZ-SO) 是 Triclabendazole 的主要血浆代谢产物,具有抗寄生虫作用。Triclabendazole sulfoxide 可以抑制膜转运蛋白 ABCG2/BCRP 的活性。

相关类别

研究领域 >> 感染

信号通路 >> 跨膜转运 >> BCRP

参考文献

[1]. Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56(7):3535-43.

[2]. Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92(3):205-10.

密度	1.69
沸点	547.6ºC at 760 mmHg
分子式	C₁₄H₉Cl₃N₂O₂S
分子量	375.65700
闪点	285ºC
精确质量	373.94500
PSA	74.19000
LogP	5.91850
蒸汽压	4.81E-12mmHg at 25°C
折射率	1.749
储存条件	2-8°C

危害声明	H413
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

三氯苯达唑

68786-66-3

~93%

三氯苯达唑亚砜

100648-13-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 22 p. 3129 - 3134

三氯苯达唑亚砜上游产品 1
CAS号68786-66-3 三氯苯达唑
三氯苯达唑亚砜下游产品 0

Fasciola hepatica: disruption of the vitelline cells in vitro by the sulphoxide metabolite of triclabendazole.

Parasitol. Res. 82(4) , 333-9, (1996)

The effects of the active sulphoxide metabolite of the fasciolicide triclabendazole (Fasinex, Ciba-Geigy) on the vitelline cells of Fasciola hepatica were determined in vitro by transmission electron ...

Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep.

Exp. Parasitol. 136 , 14-9, (2014)

The flukicidal compound triclabendazole (TCBZ) has a complex metabolic pattern that includes the systemic presence of its sulphoxide (TCBZ.SO) and sulphone (TCBZ.SO2) metabolites, usually recovered fr...

Fasciola gigantica: tegumental surface alterations following treatment in vitro with the sulphoxide metabolite of triclabendazole.

Parasitol. Res. 88(4) , 315-25, (2002)

The effect of the active sulphoxide metabolite of the fasciolicide triclabendazole on the surface morphology of the tropical liver fluke, Fasciola gigantica, was determined in vitro by scanning electr...

Tcbz-SX

Triclabendazole sulfoxide

1H-Benzimidazole,6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl)

5-chloro-6-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole

triclabendazole sulphoxide