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2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸用途

Metronidazole acetic acid 是 Metronidazole 的代谢产物,在细菌中具有诱变活性。Metronidazole 是一种硝基咪唑类抗生素,杀螨剂和抗原生动物剂,特别用于厌氧细菌和原生动物。

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2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸名称

[ CAS 号 ]:
1010-93-1

[ 中文名 ]:
甲硝唑杂质G

[ 英文名 ]:
Metronidazole acetic acid

[英文别名 ]:

2-Methyl-5-nitro-1H-imidazole-1-acetic acid
1-Carboxymethyl-2-methyl-5-nitro-imidazol
2-methyl-5-nitroimidazole-1-acetic acid
Metronidazole acetic acid

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. M Chacko, et al. Studies on the Possible Mutagenic Action of Metronidazole. Indian J Exp Biol. 1987 Apr;25(4):240-3.

[2]. M D Mudry, et al. Mutagenic Bioassay of Certain Pharmacological Drugs: III. Metronidazole (MTZ). Mutat Res. 1994 Mar 1;305(2):127-32.

[3]. In Schaechter, M.; Engleberg, N. C.; DiRita, V. J. et al. Schaechter's Mechanisms of Microbial Disease. Hagerstown, MD: Lippincott Williams & Wilkins. p. 28.

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸物理化学性质

[ 密度 ]:
1.6g/cm3

[ 沸点 ]:
475.9ºC at 760mmHg

[ 分子式 ]:
C₆H₇N₃O₄

[ 分子量 ]:
185.13700

[ 闪点 ]:
241.6ºC

[ 精确质量 ]:
185.04400

[ PSA ]:
100.94000

[ LogP ]:
0.70750

[ 蒸汽压 ]:
7.28E-10mmHg at 25°C

[ 折射率 ]:
1.646

[ 储存条件 ]:
2-8°C，干燥，密封

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸MSDS

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933290090

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸合成路线

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸上下游产品

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸上游产品

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸下游产品

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸文献

Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.

Clin. Chem. 30(5) , 784-7, (1984)

Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples de...

Steady-state pharmacokinetics of metronidazole in Crohn's disease.

Biopharm. Drug Dispos. 8(3) , 249-59, (1987)

The pharmacokinetics of metronidazole (MTZ) were studied in six Crohn's disease patients after multiple oral daily doses of 250, 500, 750, and 1000 mg day-1. Pharmacokinetic indices were found to be i...

Relative susceptibilities of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to Metronidazole and its two major metabolites.

Sex. Transm. Dis. 7(4) , 157-60, (1980)

The susceptibilities of strains of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to metronidazole and its principal oxidative metabolites (1-[2-hydroxy...

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