2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸
2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸结构式
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常用名 | 2-(2-甲基-5-硝基-1H-咪唑-1-基)乙酸 | 英文名 | Metronidazole acetic acid |
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| CAS号 | 1010-93-1 | 分子量 | 185.13700 | |
| 密度 | 1.6g/cm3 | 沸点 | 475.9ºC at 760mmHg | |
| 分子式 | C6H7N3O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 241.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.
Clin. Chem. 30(5) , 784-7, (1984) Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples deproteinized with trichloroacetic acid (50 g/L final concent... |
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Steady-state pharmacokinetics of metronidazole in Crohn's disease.
Biopharm. Drug Dispos. 8(3) , 249-59, (1987) The pharmacokinetics of metronidazole (MTZ) were studied in six Crohn's disease patients after multiple oral daily doses of 250, 500, 750, and 1000 mg day-1. Pharmacokinetic indices were found to be independent of the dose administered. The half-life, volume ... |
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Relative susceptibilities of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to Metronidazole and its two major metabolites.
Sex. Transm. Dis. 7(4) , 157-60, (1980) The susceptibilities of strains of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to metronidazole and its principal oxidative metabolites (1-[2-hydroxyethyl]-2-hydroxymethyl-5-nitroimidazole) ("hydroxy" metabol... |
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Assay of metronidazole by HPLC compared with microbial method.
Scand. J. Gastroenterol. Suppl. 91 , 31-43, (1984) A high-performance liquid chromatography (HPLC) method for the assay of metronidazole and its 2-hydroxymethyl metabolite in sera was compared with a microbiological method, an agar well diffusion technique with Clostridium perfringens as indicator strain. The... |
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Systemic concentrations of metronidazole and its main metabolites after intravenous oral and vaginal administration.
Gynecol. Obstet. Invest. 24(3) , 200-7, (1987) Metronidazole kinetics was studied in 5 healthy women after a single dose given intravenously, orally or vaginally, 500, 400 and 500 mg, respectively. Serum levels of the drug and of its hydroxy and acid metabolites were assessed. The results after intravenou... |
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Pharmacokinetics of metronidazole in patients undergoing continuous ambulatory peritoneal dialysis.
Antimicrob. Agents Chemother. 25(3) , 306-10, (1984) The pharmacokinetics of metronidazole, its biologically active alcohol metabolite, and its inactive acid metabolite were studied in five noninfected patients undergoing continuous ambulatory peritoneal dialysis and five patients undergoing hemodialysis. The l... |