Jasplakinolide

Jasplakinolide用途

Jasplakinolide 是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂,可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白,Kd 值为 15 nM。Jasplakinolide 是一种来自海洋海绵 (marine sponge) 的天然环状肽,具有抗真菌和抗肿瘤活性。

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Jasplakinolide名称

[ CAS 号 ]:
102396-24-7

[ 英文名 ]:
Jasplakinolide

[英文别名 ]:

Jaspamide
jasplakinolide
jasplakinolide,jaspis johnstoni

Jasplakinolide生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞骨架 >> Arp2/3复合物

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[体外研究]

茉莉酸内酯对PC3前列腺癌细胞的抑制作用为35nm的IC50[2]。茉莉酸内酯(10μM；2小时)在有丝分裂过程中产生双核细胞。茉莉酸诱导弓形虫速殖子中含F-肌动蛋白的顶端延伸[2]。茉莉花素内酯(1毫米；60分钟)诱导弓形虫速殖子形成含有肌动蛋白的顶端延伸[2]。

[参考文献]

[1]. Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71.

[2]. Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.

Jasplakinolide物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
968.3±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₆H₄₅BrN₄O₆

[ 分子量 ]:
709.670

[ 闪点 ]:
539.4±34.3 °C

[ 精确质量 ]:
708.252258

[ PSA ]:
140.83000

[ LogP ]:
4.24

[ 外观性状 ]:
薄膜

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.553

[ 储存条件 ]:
-20°C

JasplakinolideMSDS

详细MSDS(安全技术说明书)

Jasplakinolide安全信息

[ 危险品运输编码 ]:
UN 3172

[ RTECS号 ]:
GX7000000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

Jasplakinolide文献

Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.

PLoS ONE 6 , e20878, (2011)

Abnormal mitochondrial function is a widely reported contributor to neurodegenerative disease including Alzheimer's disease (AD), however, a mechanistic link between mitochondrial dysfunction and the ...

P2Y2 receptor signaling in neutrophils is regulated from inside by a novel cytoskeleton-dependent mechanism.

Exp. Cell Res. 336 , 242-52, (2015)

Functional selectivity, a process by which G-protein coupled receptors (GPCRs) can activate one signaling route while avoiding another, is regulated by ligand-mediated stabilization of specific recept...

Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli.

Mol. Biol. Cell 23(18) , 3663-72, (2012)

Fertilization changes the structure and function of the cell surface. In sea urchins, these changes include polymerization of cortical actin and a coincident, switch-like increase in the activity of t...

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