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N,O-二丹磺酰基-L-酪氨酸环己基铵盐

N,O-二丹磺酰基-L-酪氨酸环己基铵盐用途

N、 O-二烷基-L-酪氨酸环己基铵是一种有效的选择性胸苷酸合成酶(TS)抑制剂,作用于大肠杆菌、干酪乳杆菌和人的TS,IC50值分别为5.0、3.4和119μM[1]。

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N,O-二丹磺酰基-L-酪氨酸环己基铵盐名称

[ CAS 号 ]:
102783-47-1

[ 中文名 ]:
N,O-二丹磺酰基-L-酪氨酸环己基铵盐

[ 英文名 ]:
N,O-Didansyl-L-tyrosine cyclohexylammonium salt

[英文别名 ]:

N,O-二丹磺酰基-L-酪氨酸环己基铵盐生物活性

[ 描述 ]:

N、 O-二烷基-L-酪氨酸环己基铵是一种有效的选择性胸苷酸合成酶(TS)抑制剂,作用于大肠杆菌、干酪乳杆菌和人的TS,IC50值分别为5.0、3.4和119μM[1]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 胸苷酸合成酶

研究领域 >> 癌症

[ 靶点 ]

IC50: 3.4 μM (LcTS)，5.0 μM (EcTS), 119 μM (hTS)[1].

[参考文献]

[1]. T A Fritz, et al. Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Chem Biol. 2001 Oct;8(10):981-95.

N,O-二丹磺酰基-L-酪氨酸环己基铵盐物理化学性质

[ 分子式 ]:
C₃₉H₄₆N₄O₇S₂

[ 分子量 ]:
746.93500

[ 精确质量 ]:
746.28100

[ PSA ]:
176.10000

[ LogP ]:
9.39750

N,O-二丹磺酰基-L-酪氨酸环己基铵盐MSDS

详细MSDS(安全技术说明书)

N,O-二丹磺酰基-L-酪氨酸环己基铵盐安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

N,O-二丹磺酰基-L-酪氨酸环己基铵盐文献

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.

Chem. Biol. 8 , 981-995, (2001)

Protein plasticity in response to ligand binding abrogates the notion of a rigid receptor site. Thus, computational docking alone misses important prospective drug design leads. Bacterial-specific inh...

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.

J. Med. Chem. 48 , 913-916, (2005)

N,O-Didansyl-L-tyrosine (DDT) represented the starting lead for further development of novel non-substrate-like inhibitors of bacterial thymidylate synthase. The N-dansyl structure modulation led to a...

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases.

ChemBioChem. 9 , 779-790, (2008)

The elucidation of the structural/functional specificities of highly conserved enzymes remains a challenging area of investigation, and enzymes involved in cellular replication are important targets f...

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