N,N-二甲基苄胺

N,N-二甲基苄胺用途

用途一:用作有机合成中间体，还可用作脱氢催化剂、防腐剂、酸中和剂等
用途二:用于有机合成
用途三:有机合成中间体，用于生产新洁而灭脱氢卤的催化剂、阻蚀剂、酸性中和剂、电子显微镜切片包埋用加速剂
用途四:本产品为有机合成中间体，如合成季铵盐等，还用于脱氢催化剂，防腐剂，酸的中和剂等
用途五:18-甲基炔诺酮，三烯高诺酮的中间体，甾体化合物全合成中D环的前体

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N,N-二甲基苄胺名称

[ CAS 号 ]:
103-83-3

[ 中文名 ]:
N,N-二甲基苄胺

[ 英文名 ]:
dimethylbenzylamine

[中文别名 ]:

[英文别名 ]:

dimethylbenzylamine
N,N-Dimethylbenzylam
N-BENZYLDIETHYLAMINE
Pentamin BDMA etc
Benzyldimethylamine
BENZYLDIETHYLAMINE
Dabco B-16
dimethylaminomethylbenzene
BDMA
EINECS 203-149-1

N,N-二甲基苄胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
181.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-75 °C

[ 分子式 ]:
C₉H₁₃N

[ 分子量 ]:
135.206

[ 闪点 ]:
54.4±0.0 °C

[ 精确质量 ]:
135.104797

[ PSA ]:
3.24000

[ LogP ]:
1.98

[ 外观性状 ]:
一种无色至淡黄色液体带有一种氨气味

[ 蒸汽压 ]:
0.9±0.3 mmHg at 25°C

[ 折射率 ]:
1.517

[ 储存条件 ]:
库房通风低温干燥,与酸分开存放

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents.

[ 水溶解性 ]:
8 g/L (20 ºC)

N,N-二甲基苄胺MSDS

N,N-二甲基苄胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DP4500000

CHEMICAL NAME :: Benzylamine, N,N-dimethyl-

CAS REGISTRY NUMBER :: 103-83-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C9-H13-N

MOLECULAR WEIGHT :: 135.23

WISWESSER LINE NOTATION :: 1N1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,43,1985

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,43,1985 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KorCJ# Personal Communication from C.J. Korpics, Sherwin-Williams Chemicals, 1310 Expressway Drive,t/ Toledo, OH 43608, Aug. 22, 1974 Volume(issue)/page/year: 22AUG1974

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/m3/2H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 5,6,1963

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/m3/2H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 5,6,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1660 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,43,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/m3/4H/26W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 5,6,1963 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83034 No. of Facilities: 142 (estimated) No. of Industries: 5 No. of Occupations: 34 No. of Employees: 23940 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83034 No. of Facilities: 110 (estimated) No. of Industries: 8 No. of Occupations: 8 No. of Employees: 2150 (estimated) No. of Female Employees: 249 (estimated)

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N,N-二甲基苄胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302 + H312 + H332-H314-H412

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R20/21/22;R34;R52/53

[ 安全声明 (欧洲) ]:
S26-S36-S45-S61

[ 危险品运输编码 ]:
UN 2619 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
DP4500000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2921499090

N,N-二甲基苄胺合成路线

N,N-二甲基苄胺上下游产品

N,N-二甲基苄胺上游产品

N,N-二甲基苄胺下游产品

N,N-二甲基苄胺制备

（1）苄和二甲胺反应而得。先向反应锅中加入二甲胺，搅拌下加入氯化苄，温度控制在25℃以下。滴加完毕，在室温下搅拌反应1h，再慢慢升高温度至55-60℃继续反应6h。然后加入液碱静置分层，取油层，用热水洗涤，减压蒸馏，收集67-72℃（1.87kpa）馏分，得苄基二甲胺。原料消耗：二甲胺2666kg/t;氯化苄860kg/t。（2）向反应釜中投入二甲胺100kg，在搅拌及水浴冷却条件下缓慢滴加115kg氯化苄，滴加完毕撤去冷却水，常温下反应2h,再用蒸汽加热至50-60℃，反应5h。反应结束后将釜中的水放掉，再用热水洗涤两次，水洗后停止搅拌，用循环水冷却，40h后将水放掉。收集料相即可得到粗品。将粗产品减压蒸馏，收集1.6kpa下、气相温度70-72℃的馏分，即可得到化学纯的N，N-二甲基苄胺。

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N,N-二甲基苄胺海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N,N-二甲基苄胺文献

Silver nanowire interactions with primary human alveolar type-II epithelial cell secretions: contrasting bioreactivity with human alveolar type-I and type-II epithelial cells.

Nanoscale 7 , 10398-409, (2015)

Inhaled nanoparticles have a high deposition rate in the alveolar units of the deep lung. The alveolar epithelium is composed of type-I and type-II epithelial cells (ATI and ATII respectively) and is ...

Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.

J. Med. Chem. 52 , 3416-9, (2009)

RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but remains limited for the determination of partition coefficients of moderate to strong basic compounds ...

Benzylamine analog binding studies as probes of the substrate sites of monoamine oxidases A and B.

Drug Metab. Rev. 31(1) , 235-45, (1999)

更多文献

N,N-二甲基苄胺

N,N-二甲基苄胺用途

N,N-二甲基苄胺名称

N,N-二甲基苄胺物理化学性质

N,N-二甲基苄胺MSDS

详细MSDS(安全技术说明书)

N,N-二甲基苄胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

N,N-二甲基苄胺安全信息

N,N-二甲基苄胺合成路线

详细合成路线

N,N-二甲基苄胺上下游产品

N,N-二甲基苄胺上游产品

N,N-二甲基苄胺下游产品

N,N-二甲基苄胺制备

N,N-二甲基苄胺海关

N,N-二甲基苄胺文献

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