肉桂醇； beta-苯丙烯醇

Cinnamyl Alcohol 从板栗花中分离得到的活性成分,抑制增加的 PPARγ 的表达,具有抗肥胖的作用。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
250.0±0.0 °C at 760 mmHg

[ 熔点 ]:
30-33 °C(lit.)

[ 分子式 ]:
C₉H₁₀O

[ 分子量 ]:
134.175

[ 闪点 ]:
124.8±14.5 °C

[ 精确质量 ]:
134.073166

[ PSA ]:
20.23000

[ LogP ]:
1.70

[ 外观性状 ]:
无色固体

[ 蒸汽密度 ]:
4.6 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.599

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.8 g/L (20 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

GE2200000

CHEMICAL NAME :

Cinnamyl alcohol

CAS REGISTRY NUMBER :

104-54-1

BEILSTEIN REFERENCE NO. :

1903999

LAST UPDATED :

199701

DATA ITEMS CITED :

10

MOLECULAR FORMULA :

C9-H10-O

MOLECULAR WEIGHT :

134.19

WISWESSER LINE NOTATION :

Q2U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2675 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

>5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

2675 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6366 mg/kg/17W-I

TOXIC EFFECTS :

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TYPE OF TEST :

DNA repair

TEST SYSTEM :

Bacteria - Bacillus subtilis

DOSE/DURATION :

10 mg/disc

REFERENCE :

OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83181 No. of Facilities: 163 (estimated) No. of Industries: 6 No. of Occupations: 36 No. of Employees: 8942 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83181 No. of Facilities: 4817 (estimated) No. of Industries: 25 No. of Occupations: 48 No. of Employees: 76974 (estimated) No. of Female Employees: 43896 (estimated)

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36;R43

[ 安全声明 (欧洲) ]:
S26-S36/37-S37/39-S24

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
2

[ RTECS号 ]:
GE2200000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2912299000

详细合成路线

肉桂醇； beta-苯丙烯醇上游产品

肉桂醇； beta-苯丙烯醇下游产品

1.桂醛还原法
在1份质量的苄醇中加入0.01份铝屑，加热至60℃反应放出氢气，温度升高至180℃，至停止放出氢气为止。苄醇铝溶液经冷却、过滤后加入到苄醇和桂醛的混合物(质量1：1)中。在0.0027MPa的条件下加热至沸，在80℃和回流比3～4下蒸出反应生成的苯甲醛，同时补加苄醇。直到蒸出理论量95%的苯甲醛后停止加料，并蒸出剩余的苄醇，然后蒸出肉桂醇粗品。再经减压精馏，收集117℃(7kPa)馏分，即为产品。
苏合香脂皂化法
桂醇以桂酸桂酯的形式天然存在于秘鲁香脂、安息香脂和苏合香脂中。将苏合香脂在10%的氢氧化钠溶液中加热皂化5h，再用乙醚萃取出水解产物桂醇，最后经减压蒸馏提纯而得成品。

2.将苏合香脂在氢氧化钠溶液中加热皂化，经萃取、减压蒸馏制得。或者用异丙烯基铝、丁醇铝或苄醇铝还原桂醛制得。

3. 烟草：BU，14。

[ 海关编码 ]: 2912299000

[ 中文概述 ]:
2912299000. 其他不含其他含氧基的环醛. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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Functional characterization of two acyltransferases from Populus trichocarpa capable of synthesizing benzyl benzoate and salicyl benzoate, potential intermediates in salicinoid phenolic glycoside biosynthesis.

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Salicinoids are phenolic glycosides (PGs) characteristic of the Salicaceae and are known defenses against insect herbivory. Common examples are salicin, salicortin, tremuloidin, and tremulacin, which ...

Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage.

Bioorg. Med. Chem. 19 , 2392-6, (2011)

In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic a...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：肉桂醇

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥98.0/20mg ￥88.0/250g ￥218.0/1kg

联系人：刘佳

产品详情：肉桂醇

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥489.0/20mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Cinnamyl alcohol

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥51.9/100g ￥279.9/1kg ￥87.9/250g ￥205.9/250mg

联系人：阿拉丁

产品详情：肉桂醇

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥91.0/250g ￥280.0/1kg ￥490.0/20mg

联系人：夏言

产品详情：[Perfemiker]肉桂醇,98%

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