乙酰乙酸甲酯
乙酰乙酸甲酯用途
用于医药工业
【用途二】
乙酰乙酸甲酯是杀菌剂恶霉灵、二甲嘧酚、乙嘧酚,杀虫剂二嗪磷、蝇毒磷、嘧啶氧磷,除草剂咪唑乙烟酸,杀鼠剂杀鼠醚、杀鼠灵等的中间体。
【用途三】
用作纤维素醚的溶剂和纤维素树脂混合溶剂的成分,也用于农药、医药、染料、高分子稳定剂等有机合成中。
乙酰乙酸甲酯名称
[ CAS 号 ]:
105-45-3
[ 中文名 ]:
乙酰乙酸甲酯
[ 英文名 ]:
Methyl acetoacetate
[中文别名 ]:
[英文别名 ]:
- EINECS 203-299-8
- Methyl 3-oxobutanoate
- Butanoic acid, 3-oxo-, methyl ester
- Methyl acetoacetate
- 3-Oxobutyric acid methyl ester
- Acetoacetic Acid Methyl Ester
- methyl acetoacetate(MAA)
- MFCD00008784
- Methyl 3-Oxobutyrate
乙酰乙酸甲酯物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
169.4±8.0 °C at 760 mmHg
[ 熔点 ]:
-28 °C
[ 分子式 ]:
C5H8O3
[ 分子量 ]:
116.115
[ 闪点 ]:
61.6±18.5 °C
[ 精确质量 ]:
116.047340
[ PSA ]:
43.37000
[ LogP ]:
0.19
[ 外观性状 ]:
无色液体
[ 蒸汽压 ]:
1.5±0.3 mmHg at 25°C
[ 折射率 ]:
1.399
[ 储存条件 ]:
2-8°C
[ 水溶解性 ]:
460 g/L (20 ºC)
乙酰乙酸甲酯MSDS
乙酰乙酸甲酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AK5775000
- CHEMICAL NAME :
- Acetoacetic acid, methyl ester
- CAS REGISTRY NUMBER :
- 105-45-3
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C5-H8-O3
- MOLECULAR WEIGHT :
- 116.13
- WISWESSER LINE NOTATION :
- 1V1VO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,815,1978
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3228 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84355 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 270 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84355 No. of Facilities: 30 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1872 (estimated) No. of Female Employees: 336 (estimated)
乙酰乙酸甲酯安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H319
[ 警示性声明 ]:
P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi:Irritant
[ 风险声明 (欧洲) ]:
R36
[ 安全声明 (欧洲) ]:
S26
[ WGK德国 ]:
1
[ RTECS号 ]:
AK5775000
[ 海关编码 ]:
2918300090
乙酰乙酸甲酯合成路线
乙酰乙酸甲酯上下游产品
乙酰乙酸甲酯上游产品
乙酰乙酸甲酯下游产品
乙酰乙酸甲酯制备
由双乙烯酮与甲醇反应制得。双乙烯酮与甲醇以浓硫酸为催化剂进行酯化,再经粗分馏、精馏得成品。双乙烯酮则由醋酸裂解而得。
精制方法:除含有游离的酸和醇外,还含有丙酮等杂质。精制时用碳酸钾或无水硫酸钠干燥后减压蒸馏。
乙酰乙酸甲酯海关
[ 海关编码 ]: 2918300090
[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸(包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物). 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
乙酰乙酸甲酯文献
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