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SU-5614游离态

SU-5614游离态用途

(Z) -SU5614是一种有效的FLT3抑制剂,在表达组成性激活FLT3的Ba/F3和AML细胞系中选择性诱导生长停滞、凋亡和细胞周期停滞[1]。

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SU-5614游离态名称

[ CAS 号 ]:
1055412-47-9

[ 中文名 ]:
SU-5614游离态

[ 英文名 ]:
SU 5614

[英文别名 ]:

SU 5614
SU5614

SU-5614游离态生物活性

[ 描述 ]:

(Z) -SU5614是一种有效的FLT3抑制剂,在表达组成性激活FLT3的Ba/F3和AML细胞系中选择性诱导生长停滞、凋亡和细胞周期停滞[1]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 蛋白酪氨酸激酶 >> FLT3

[参考文献]

[1]. Spiekermann K, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003 Feb 15;101(4):1494-504.

SU-5614游离态物理化学性质

[ 分子式 ]:
C₁₅H₁₃ClN₂O

[ 分子量 ]:
272.73000

[ 精确质量 ]:
272.07200

[ PSA ]:
48.38000

[ LogP ]:
3.86270

[ 储存条件 ]:
2-8°C，干燥密封

SU-5614游离态安全信息

[ 危害声明 ]:
H413

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

SU-5614游离态海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

SU-5614游离态文献

Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia.

Oncotarget 6 , 38804-15, (2015)

Internal tandem duplications within the juxtamembrane region of the FMS-like tyrosine kinase receptor FLT3 (FLT3-ITD) represents one of the most common mutations in patients with acute myeloid leukemi...

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.

Biol. Open 4 , 1063-76, (2015)

Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 s...

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