溴代丙烷

【用途一】
用于合成医药、农药、染料、香料等
【用途二】
用于有机合成及制药工业
【用途三】
1-溴丙烷作为一种有机合成原料，在农药上用于合成有机磷杀虫杀螨剂硫丙磷、丙硫磷、丙溴磷等，也可用于医药、染料、香料工业，以及作为格氏试剂原料。
【用途四】
用于医药、农药、染料、香料等制造，还用作Grignard试剂的原料，药物丙硫硫胺，丙磺舒的中间体。
【用途五】
用于医药；农药；染料；香料等制造，还用作Grignard试剂的原料，药物丙硫硫胺，丙磺舒的中间体。

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
71.7±3.0 °C at 760 mmHg

[ 熔点 ]:
-110 °C

[ 分子式 ]:
C₃H₇Br

[ 分子量 ]:
122.992

[ 闪点 ]:
-4.5 ºC

[ 精确质量 ]:
121.973106

[ LogP ]:
2.21

[ 外观性状 ]:
无色透明液体

[ 蒸汽密度 ]:
4.3 (vs air)

[ 蒸汽压 ]:
133.4±0.1 mmHg at 25°C

[ 折射率 ]:
1.432

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stability Flammable - note low flash point. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
2.5 g/L (20 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TX4110000

CHEMICAL NAME :

Propane, 1-bromo-

CAS REGISTRY NUMBER :

106-94-5

LAST UPDATED :

199710

DATA ITEMS CITED :

8

MOLECULAR FORMULA :

C3-H7-Br

MOLECULAR WEIGHT :

123.01

WISWESSER LINE NOTATION :

E3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 101,321,1982

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

253 gm/m3/30M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966- Volume(issue)/page/year: 7,35,1975

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2950 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,102,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2530 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,102,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

98408 mg/m3/30M/1W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,139,1944 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2 gm/kg

SEX/DURATION :

male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 101,321,1982

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H315-H319-H335-H336-H351-H360FD-H373-H412-H420

[ 警示性声明 ]:
P201-P210-P280-P308 + P313-P370 + P378-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R36/37/38;R48/20;R60;R63;R67

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 2344 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
TX4110000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2903399090

详细合成路线

溴代丙烷上游产品

溴代丙烷下游产品

1.由正丙醇与氢溴酸反应而得。将氢溴酸加入浓硫酸中，再加入正丙醇，加热回流0.5h。于70-75℃将生成的溴丙烷全部蒸出，然后用浓盐酸洗，再用碳酸钠中和至pH为7。用无水硫酸钠干燥，过滤，滤液蒸馏，收集69-74℃馏分，得溴丙烷。

2.由正丙醇与溴化钠反应而得。将正丙醇和水、溴化钠一起加热至回流，保持69-72℃滴加硫酸，加毕，继续回流2h。蒸馏，收集68-100℃馏出液，用碳酸钠溶液洗至中性，再蒸馏，收集68-76℃馏出液即溴丙烷。另外，在红磷存在下，正丙醇与溴反应也可制备溴丙烷。

3.制法：

于反应瓶中加入48%的氢溴酸500g，水浴冷却，搅拌下慢慢加入浓硫酸150g(82mL),再加入正丙醇(2)144g（2.4mol），慢慢加热，并由滴液漏斗滴加浓硫酸65mL，同时蒸出生成的1-溴丙烷。接引管伸入接受瓶中水面下，接受瓶用冰水冷却。待无溴丙烷蒸出时，停止反应。分出馏出物中的粗溴丙烷，依次用水、5%的碳酸钠溶液、水洗涤，无水氯化钙干燥。水浴加热蒸馏，收集70～72℃的馏分，得1-溴丙烷(1)^①255g,收率86%。注：①也用溴化钠、硫酸和丙醇反应来制备1-溴丙烷。

[ 海关编码 ]: 2903399090

[ 中文概述 ]:
2903399090. 其他无环烃的氟化、溴化或碘化衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903399090. brominated,fluorinated or iodinated derivatives of acyclic hydrocarbons. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Facile charge-displacement at silicon gives spaced-out reaction.

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Apoptosis contributes to testicular toxicity induced by two isomers of bromopropanes.

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：1-溴丙烷

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥165.0/500g

联系人：刘佳

产品详情：1-溴丙烷

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥122.0/500g ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：1-溴丙烷

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公司名：广东翁江化学试剂有限公司

区域：韶关市翁源县

价格：
￥120.0/500g

联系人：朱丽丹

产品详情：1-溴丙烷

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