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HZ52

HZ52用途

HZ52是一种有效、可逆的5-脂氧合酶抑制剂,在完整的人类多形核白细胞中以0.7μM的IC50阻断白三烯的合成[1]。

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HZ52名称

[ CAS 号 ]:
1077626-51-7

[ 英文名 ]:
HZ52

[英文别名 ]:

HZ52生物活性

[ 描述 ]:

HZ52是一种有效、可逆的5-脂氧合酶抑制剂,在完整的人类多形核白细胞中以0.7μM的IC50阻断白三烯的合成[1]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[参考文献]

[1]. Greiner C, et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 2011 Sep;164(2b):781-93.

HZ52物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
625.3±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₄H₂₆ClN₃O₂S

[ 分子量 ]:
456.000

[ 闪点 ]:
332.0±31.5 °C

[ 精确质量 ]:
455.143433

[ PSA ]:
100.41000

[ LogP ]:
9.07

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.641

HZ52安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

HZ52合成路线

详细合成路线

HZ52文献

Functional p53 can modulate the relationship between E2F-1 expression and tumor kinetics in Hodgkin lymphoma.

Leuk. Lymphoma 56(3) , 748-54, (2015)

E2F-1 is the best-described member of the E2F family of transcriptional factors and is particularly interesting in view of its often opposing roles. Our purpose was to examine the immunohistochemical ...

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