3-甲基吡啶
3-甲基吡啶用途
用于医药工业，也用作染料中间体、树脂中间体、杀虫剂及防水剂等
【用途二】
3-甲基吡啶又名β-甲基吡啶、3-皮考林，是一种有机合成中间体和溶剂，在农药上作为杀虫剂吡虫啉和啶虫脒的中间体，用于合成下一步中间体3-甲基吡啶-N-氧化物，也可用作医药中间体、染料中间体、树脂中间体等。
【用途三】
主要用于制造维生素B6、烟酸和烟酰胺、尼可拉明和强心剂等药物；也可用作溶剂、酒精变性剂、染料中间体、树脂中间体、橡胶硫化促进剂、杀虫剂、防水剂的原料，以及胶片感光剂的添加物。
【用途四】
主要用于制造维生素B，烟酸，强心剂等，也可用作溶剂，酒精变性剂，各种中间体，杀虫剂
3-甲基吡啶名称
[ CAS 号 ]:
108-99-6
[ 中文名 ]:
3-甲基吡啶
[ 英文名 ]:
3-Mepy
[中文别名 ]:
[英文别名 ]:
- β-Picoline
- BETAP
- B-Picoline
- 5-methylpyridine
- 3-Picoline
- Pyridine, 3-methyl-
- 3-Methylpyidine
- 3-methyl-pyridin
- 3-Methylpyridine
- T6NJ C1
3-甲基吡啶物理化学性质
[ 密度 ]:
0.9±0.1 g/cm3
[ 沸点 ]:
143.5±3.0 °C at 760 mmHg
[ 熔点 ]:
−19 °C(lit.)
[ 分子式 ]:
C6H7N
[ 分子量 ]:
93.127
[ 闪点 ]:
36.1±0.0 °C
[ 精确质量 ]:
93.057846
[ PSA ]:
12.89000
[ LogP ]:
1.19
[ 外观性状 ]:
透明琥珀色液体
[ 蒸汽密度 ]:
3.2 (vs air)
[ 蒸汽压 ]:
6.7±0.3 mmHg at 25°C
[ 折射率 ]:
1.501
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放
[ 稳定性 ]:
Stable. Flammable. Hygroscopic. Incompatible with oxidizing agents.
[ 水溶解性 ]:
soluble
3-甲基吡啶MSDS
3-甲基吡啶毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TJ5000000
- CHEMICAL NAME :
- 3-Picoline
- CAS REGISTRY NUMBER :
- 108-99-6
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C6-H7-N
- MOLECULAR WEIGHT :
- 93.14
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534823
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534823 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11820 mg/m3/5H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534823
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,920,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 596 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 88,82,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 298 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 88,82,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Lungs, Thorax, or Respiration - pulmonary emboli Gastrointestinal - other changes
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534823
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2579 No. of Facilities: 34 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 5202 (estimated) No. of Female Employees: 390 (estimated)
3-甲基吡啶安全信息
[ 符号 ]:
GHS02, GHS05, GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H226-H302-H311 + H331-H314
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R10;R22;R36/37/38
[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39-S45-S36
[ 危险品运输编码 ]:
UN 2313 3/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
TJ5000000
[ 包装等级 ]:
III
[ 危险类别 ]:
3
[ 海关编码 ]:
29333999
3-甲基吡啶合成路线
3-甲基吡啶上下游产品
3-甲基吡啶上游产品
3-甲基吡啶下游产品
3-甲基吡啶制备
1.从煤焦化副产中回收，也用合成法生产。由乙醛、甲醛和氨反应。采用SiO2-Al2O2-Bi2O3为催化剂，原料的摩尔配比为乙醛：37%甲醛：氨=1.648：3.096，在432℃进行反应，吡啶收率48.4%，3-甲基吡啶收率为27.0%。改变催化剂组成及其他反应条件，可调节产物的生成比例。选择合适的配料经和催化剂，用六次甲基四胺代替氨，3-甲基吡啶的收率可达59.7%。
2.精制方法：与2-甲基吡啶精制方法相同。粗制的3-甲基吡啶含杂质较多，通过与水的共沸蒸馏可除去大部分杂质。用分馏的方法分离4-甲基吡啶和2,6-二甲基吡啶比较困难，大多利用其加成化合物的溶解度不同以达到分离的目的。例如用硫酸铜溶液处理后，收集加成产物，用氢氧化钙分解后进行水蒸气蒸馏精制。
3-甲基吡啶海关
[ 海关编码 ]: 2933399090
[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
3-甲基吡啶文献
Phys. Rev. Lett. 109(24) , 248302, (2012)
By using the critical Casimir force, we study the attractive strength dependent aggregation of colloids with and without gravity by means of near field scattering. Significant differences were seen be...
Gordonia nitida sp. nov., a bacterium that degrades 3-ethylpyridine and 3-methylpyridine.Int. J. Syst. Evol. Microbiol. 50 Pt 3 , 1203-10, (2000)
A bacterial strain, LE31T, which is capable of degrading 3-ethylpyridine and 3-methylpyridine, was isolated from an industrial wastewater and was taxonomically studied by using a polyphasic approach. ...
Pyridines in cigarette smoke inhibit hamster oviductal functioning in picomolar dosesReprod. Toxicol. 17(2) , 191-202, (2003)
Past studies showed that chemicals in cigarette smoke inhibit oviductal functioning in vivo and in vitro. The purposes of this study were to identify individual toxicants in cigarette smoke solutions ...
相关化工产品/化学物质：
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价格：
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产品详情：3-甲基吡啶
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥108.0/500ml
联系人：刘佳
产品详情：3-甲基吡啶
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1mg
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￥需询单/1mg
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公司名：济南世纪通达化工有限公司
区域：济南市天桥区
价格：
￥32500.0/1ton
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联系人：王经理
产品详情：3-甲基吡啶
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相关化合物
【3-甲基吡啶】化源网提供3-甲基吡啶CAS号108-99-6，3-甲基吡啶MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询3-甲基吡啶上化源网，专业又轻松。>>电脑版：3-甲基吡啶
标题：3-甲基吡啶_MSDS_用途_密度_3-甲基吡啶CAS号【108-99-6】_化源网 地址：https://m.chemsrc.com/mip/cas/108-99-6_832369.html