硼烷吡啶络合物

【用途一】
用作医药中间体
【用途二】
用于还原和硼氢化反应。
【用途三】
吡啶硼烷（110-51-0）是制备硼取代中间相沥青的原料药。

[ 密度 ]:
0.929 g/mL at 20 °C

[ 沸点 ]:
102 °C (0.37505 mmHg)

[ 熔点 ]:
10-11 °C(lit.)

[ 分子式 ]:
C₅H₈BN

[ 分子量 ]:
92.935

[ 闪点 ]:
70 °F

[ 精确质量 ]:
93.074982

[ PSA ]:
4.93000

[ 外观性状 ]:
透明至琥珀色液体

[ 蒸汽压 ]:
22.8mmHg at 25°C

[ 折射率 ]:
n20/D 1.532(lit.)

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
reacts slowly

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

US3675000

CHEMICAL NAME :

Pyridine compd. with boron hydride

CAS REGISTRY NUMBER :

110-51-0

LAST UPDATED :

199709

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C5-H8-B-N

MOLECULAR WEIGHT :

92.95

WISWESSER LINE NOTATION :

T6NJ XBHHHH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

95400 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

64800 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

54 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301-H310 + H330-H315-H319

[ 警示性声明 ]:
P210-P260-P280-P284-P301 + P310-P302 + P350

[ 危害码 (欧洲) ]:
F:Flammable;T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R10;R15;R20;R24/25;R26;R36/37/38;R44

[ 安全声明 (欧洲) ]:
S26-S36/37-S43-S45-S36/37/39-S28A

[ 危险品运输编码 ]:
UN 1992 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
US3675000

[ 包装等级 ]:
II

[ 危险类别 ]:
4.3

详细合成路线

硼烷吡啶络合物上游产品

硼烷吡啶络合物下游产品

将干燥的氯化氢气体通入吡啶的无水乙醚溶液中，滤出固体吡啶盐酸盐，将其干燥后悬浮于吡啶中，加入硼氢化钠的吡啶溶液，在室温下反应。然后滤出反应物中的氯化钠沉淀，在50℃减压蒸除吡啶，加入等体积的无水乙醚，使未反应的吡啶盐酸盐沉淀。过滤；减压蒸除乙醚，得成品。

Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions.

Macromol. Biosci. 15 , 1283-95, (2015)

Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a...

Hydroboration with pyridine borane at room temperature.

J. Am. Chem. Soc. 127 , 5766-5767, (2005)

Treatment of pyridine borane (Py.BH3) with iodine, bromine, or strong acids affords activated Py.BH2X complexes that are capable of hydroborating alkenes at room temperature. Evidence is presented for...

Global amine and acid functional group modification of proteins.

Anal. Chem. 80(3) , 713-20, (2008)

A sequential reaction methodology is employed for the complete derivatization of protein thiols, amines, and acids in high purity under denaturing conditions. Following standard thiol alkylation, prot...

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价格：

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公司名：上海吉至生化科技有限公司

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￥88.0/5g ￥258.0/25g

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥570.9/100g ￥170.9/25g ￥308.9/50g ￥56.9/5g

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥65.0/5ml ￥183.0/25ml ￥592.0/100ml ￥2554.0/500ml

联系人：夏言

产品详情：[Perfemiker]硼烷吡啶络合物,95%

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