己二腈
己二腈用途
已二腈主要用于生产聚酰胺纤维的中间体已二胺，橡胶促进剂和防锈剂，也用作洗涤剂的添加剂，丙烯腈、甲基丙烯腈和甲基丙烯酸甲酯三元共聚体的纺丝溶剂，聚氯乙烯纤维湿纺和干纺溶剂，聚酰胺的着色剂，织物漂白剂的助剂，醋酸酯、丙酸酯、丁酸酯和混合酯增塑剂；以及作为芳经抽提的萃取剂等。
己二腈名称
[ CAS 号 ]:
111-69-3
[ 中文名 ]:
己二腈
[ 英文名 ]:
Adiponitrile
[中文别名 ]:
[英文别名 ]:
- 1,4-Dicyanobutane
- Tetramethylene Dicyanide
- Adiponitrile
- MFCD00001975
- EINECS 203-896-3
- Adipic acid dinitrile
- Adipinonitril
- Hexanedinitrile
己二腈物理化学性质
[ 密度 ]:
0.9±0.1 g/cm3
[ 沸点 ]:
296.1±13.0 °C at 760 mmHg
[ 熔点 ]:
1-3 °C(lit.)
[ 分子式 ]:
C6H8N2
[ 分子量 ]:
108.141
[ 闪点 ]:
149.0±13.7 °C
[ 精确质量 ]:
108.068748
[ PSA ]:
47.58000
[ LogP ]:
-0.32
[ 外观性状 ]:
透明无色至略黄色液体
[ 蒸汽密度 ]:
3.7 (vs air)
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.432
[ 储存条件 ]:
库房通风低温干燥,与酸类、氧化剂、食品添加剂分开存放
[ 水溶解性 ]:
90 g/L (20 ºC)
[ 凝固点 ]:
1℃
己二腈MSDS
己二腈毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AV2625000
- CHEMICAL NAME :
- Adiponitrile
- CAS REGISTRY NUMBER :
- 111-69-3
- BEILSTEIN REFERENCE NO. :
- 1740005
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C6-H8-N2
- MOLECULAR WEIGHT :
- 108.16
- WISWESSER LINE NOTATION :
- NC4CN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 155 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(12),40,1984
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1710 mg/m3/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - change in acuity Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,76,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 172 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 57,88,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(12),40,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925- Volume(issue)/page/year: 46,221,1955 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 493 mg/m3/6H/4W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 30,199,1990
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 99 mg/m3/6H/13W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 30,199,1990
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3028 ug/m3/5H/26W-I
- TOXIC EFFECTS :
- Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(9),64,1981 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1120 mg/kg
- SEX/DURATION :
- female 6-19 day(s) after conception
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,33,1986 *** REVIEWS *** ACGIH TLV-TWA 8.8 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ADIPONITRILE-air:10H TWA 4 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4253 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 478 (estimated) No. of Female Employees: 41 (estimated)
己二腈安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H332
[ 警示性声明 ]:
Missing Phrase - N15.00950417-P261
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R23/25;R36/38
[ 安全声明 (欧洲) ]:
S26-S36-S45-S39
[ 危险品运输编码 ]:
UN 2205 6.1/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
AV2625000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2926909020
己二腈合成路线
己二腈上下游产品
己二腈上游产品
己二腈下游产品
己二腈制备
目前工业上生产已二腈的方法主要是已二酸氨化法、丁二烯法及丙烯腈二聚法，其中已二酸氨化法工业化最早，技术比较成熟，应用最大。
1.己二酸氨化法：将己二酸和过量的氨在催化剂磷酸或其盐类或酯类存在下，在270-290℃温度下进行反应，生成己二酸二铵，然后加热脱水，生成粗己二腈，经精馏得产品。原料消耗定额：已二酸1606kg/t、液氨370kg/t、氢氧化钠36kg/t。
2.丁二烯法：又分氯化氰化法和直接氢氰化法。
3.丙烯腈电解二聚法：电解液是对甲苯四乙胺磺酸盐，温度50-60℃，已二腈收率92-95%。丙烯腈加氢二聚过程也可采用钌催化剂在200-300℃，0.1-0.3MPa下气相催化加氢的方法。原料消耗定额：丙烯腈1100kg/t、硫酸80kg/t。
4.己二酰胺在胺基磺酸铵作用下，脱水即可生成己二腈：
己二腈海关
[ 海关编码 ]: 2926909020
[ 中文概述 ]:
2926909020 己二腈。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2926909020 adiponitrile。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%
己二腈文献
Biochem. J. 415 , 401-7, (2008)
Nitrilase from Rhodococcus rhodochrous ATCC 33278 hydrolyses both aliphatic and aromatic nitriles. Replacing Tyr-142 in the wild-type enzyme with the aromatic amino acid phenylalanine did not alter sp...
Variable interaction network based variable selection for multivariate calibration.Anal. Chim. Acta 599(1) , 24-35, (2007)
Multivariate calibration problems often involve the identification of a meaningful subset of variables, from a vast number of variables for better prediction of output variables. A new graph theoretic...
Evaluation of the teratogenic potential of three aliphatic nitriles in the rat.Fundam. Appl. Toxicol. 7(1) , 33-40, (1986)
Acetonitrile (ACN), adiponitrile (ADN), and propionitrile (PN), were evaluated for embryotoxic and teratogenic potential in rats. Mated Sprague-Dawley rats were administered one of the three nitriles ...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥108.0/100ml
￥335.0/500ml
联系人：刘佳
产品详情：己二腈
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：Adiponitrile
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1mg
￥需询单/1mg
￥需询单/1g
联系人：阿拉丁李高志
产品详情：己二腈
公司名：山东金悦源新材料有限公司
区域：济南市天桥区
价格：
￥30000.0/1ton
联系人：王思兵
产品详情：己二腈
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相关化合物
【己二腈】化源网提供己二腈CAS号111-69-3，己二腈MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询己二腈上化源网，专业又轻松。>>电脑版：己二腈
标题：己二腈_MSDS_用途_密度_己二腈CAS号【111-69-3】_化源网 地址：https://m.chemsrc.com/mip/cas/111-69-3_1114727.html