1,6-己二胺

1,6-己二胺用途

【用途一】
用于有机合成和高分子化合物的聚合
【用途二】
用作尼龙66、聚氨酯泡沫塑料的原料及环氧树脂固化剂
【用途三】
本品绝大部分用于合成尼龙66和610树脂，也用以合成聚氨酯树脂、离子交换树脂和亚己基二异氰酸酯，以及用作脲醛树脂、环氧树脂等的固化剂，有机交联剂等，还用作纺织和造纸工业的稳定剂、漂白剂，铝合金的抑制腐蚀剂和氯丁橡胶乳化剂等。已二胺与盐酸在28℃以下成盐得到1,6-已二胺盐酸盐（[6055-52-3]），可用来生产杀菌剂洗必泰乙酸盐。已二胺在粘接剂、航空涂料和橡胶硫化促进剂等生产中也有一些应用。
【用途四】
有机合成，尼龙66中间体。

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1,6-己二胺名称

[ CAS 号 ]:
124-09-4

[ 中文名 ]:
1,6-己二胺

[ 英文名 ]:
1,6-Hexanediamine

[中文别名 ]:

[英文别名 ]:

1,6-Diaminohexane
1,6-Hexamethylenediamine
1,6-Hexanediamine
EINECS 204-679-6
Hexamethylenediamine
MFCD00008243

1,6-己二胺物理化学性质

[ 密度 ]:
0.89 g/mL at 25 °C(lit.)

[ 沸点 ]:
204-205 °C

[ 熔点 ]:
42-45 °C(lit.)

[ 分子式 ]:
C₆H₁₆N₂

[ 分子量 ]:
116.20500

[ 闪点 ]:
201 °F

[ 精确质量 ]:
116.13100

[ PSA ]:
52.04000

[ LogP ]:
1.86480

[ 外观性状 ]:
白色至奶油色固体

[ 蒸汽密度 ]:
4 (vs air)

[ 蒸汽压 ]:
0.0821mmHg at 25°C

[ 折射率 ]:
n20/D 1.439(lit.)

[ 储存条件 ]:
库房通风低温干燥,与酸类和氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, organic materials.

[ 水溶解性 ]:
490 g/L (20 ºC)

1,6-己二胺MSDS

详细MSDS(安全技术说明书)

1,6-己二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO1180000

CHEMICAL NAME :: 1,6-Hexanediamine

CAS REGISTRY NUMBER :: 124-09-4

BEILSTEIN REFERENCE NO. :: 1098307

LAST UPDATED :: 199712

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C6-H16-N2

MOLECULAR WEIGHT :: 116.24

WISWESSER LINE NOTATION :: Z6Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >950 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1090-0979

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,SEP1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(11),110,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,74,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02313

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/m3/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 27,1,1970

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 215 mg/m3/6H/13W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,504,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 360 ug/m3/17W-I

TOXIC EFFECTS :: Cardiac - other changes Vascular - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 23(11),71,1958 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - hepatobiliary system

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 7,259,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1840 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 7,259,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 77 gm/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,490,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 66500 mg/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,490,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 414 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,237,1983 *** REVIEWS *** ACGIH TLV-TWA 2.3 mg/m3 (0.5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83335 No. of Facilities: 62 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 1093 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83335 No. of Facilities: 879 (estimated) No. of Industries: 9 No. of Occupations: 24 No. of Employees: 31036 (estimated) No. of Female Employees: 4686 (estimated)

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1,6-己二胺安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312-H314-H335

[ 警示性声明 ]:
P301 + P312 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R21/22;R34;R37

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S22-S27

[ 危险品运输编码 ]:
UN 2735 8/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MO1180000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2921229000

1,6-己二胺合成路线

详细合成路线

1,6-己二胺上下游产品

1,6-己二胺上游产品

1,6-己二胺下游产品

1,6-己二胺制备

生产方法简述：目前生产己二胺的工业方法较多，根据所用原料的不同有己二酸法、丁二烯法、丙烯腈法、己二醇法和己内酰胺法。其中己二酸法、丁二烯法和丙烯腈二聚法是经过中间物己二腈加氢生成己二胺，目前，几乎所有大规模生产己二胺的方法都是己二腈催化加氢法。1.工业上己二腈催化加氢有高压法和低压法两种。（1）高压法采用钴-铜催化剂，反应温度100-135℃，压力60-65MPa；也可采用铁催化剂，反应温度100-180℃，压剂可采用液氨，有时还加入芳烃（如甲苯）。己二胺的选择性约90-95%。生产中，将液态已腈、甲苯和氨与含氢氨以及少量的己二腈和甲苯的气体混合物通入装有钴-铜催化剂的反应器，生成的粗己二胺导出后，先使其与水进行共沸蒸馏，然后再通过几次真空蒸馏即得到适于制造尼龙66的高纯度产品。

（2）低压法采用骨架镍、铁-镍或铬-镍催化剂，反应在氢氧化钠溶液中进行。反应温度约75℃，压力为3MPa，己二胺的选择性可达99%。为了防止催化剂中毒，对原料己二腈的纯度要求很高。

2.以己二酸为原料的方法此法是将己二酸蒸气与过量的氨一起通过加热至340℃的硅胶等脱水催化剂，生成己二腈，然后在其中加入甲醇和液氨，用硅藻土镍为催化剂，在90-100℃下，以10.1325-20.265MPa氢进行还原得成品。

3.己内酰胺法一般用于处理已内酰胺等小型生产装置上。它是由己内酰胺与氨在磷酸盐（如锰、铝、钙、钡或锌的磷酸盐）催化剂存在下，进行气相反应生成氨基乙腈，反应温度350℃，收率几乎达100%。生成的氨基己腈再进行加氢反应生成己二胺，这一过程与己二腈加氢相似。丁二烯法（1）氯化氰化法：1，3-丁二烯与氯气于200-250℃在氯化反应器中进行氯化反应，生成1，4-二氯-2-丁烯（占66%）和3，4-二氯-1-丁烯（占33%）。二氯丁烯化合物，在碳酸钙存在下，在100-150℃下，与氢氧化钠或铵为催化剂，在50-100℃下进行异构化反应，生成1，4-二氰基-1-丁烯。1，4-二氰基-1-丁烯以钯为催化剂，于常压和250℃的条件下进行气相加氢，制得乙二腈。乙二腈催化加氢即得乙二胺。

（2）直接氢氰化法：将1，3-丁二烯在催化剂存在下与氢氰酸进行液相反应，控制反应温度100℃，生成戊烯腈的异构体混合物。混合物经分离并将异构体异构为直链戊烯腈后，再与氢氰酸进行加成，生成乙二腈，乙二腈经催化加氢即得乙二胺。

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1,6-己二胺海关

[ 海关编码 ]: 2921229000

[ 中文概述 ]:
2921229000 六亚甲基二胺及其他盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921229000 hexamethylenediamine and its salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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1,6-己二胺

1,6-己二胺用途

1,6-己二胺名称

1,6-己二胺物理化学性质

1,6-己二胺MSDS

详细MSDS(安全技术说明书)

1,6-己二胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

1,6-己二胺安全信息

1,6-己二胺合成路线

详细合成路线

1,6-己二胺上下游产品

1,6-己二胺上游产品

1,6-己二胺下游产品

1,6-己二胺制备

1,6-己二胺海关

1,6-己二胺文献

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