< 生产厂家价格 >

微囊藻毒素RR

微囊藻毒素RR用途

微囊藻毒素RR(Cyanoviridin RR)是一种有效的口服活性蛋白磷酸酶抑制剂。微囊藻毒素RR诱导小鼠肝细胞凋亡和内质网应激[1][2]。

点击显示

微囊藻毒素RR名称

[ CAS 号 ]:
111755-37-4

[ 中文名 ]:
微囊藻毒素RR

[ 英文名 ]:
Microcystin RR

[英文别名 ]:

MFCD00871765
Microcystin RR
microcystin-RR

微囊藻毒素RR生物活性

[ 描述 ]:

微囊藻毒素RR(Cyanoviridin RR)是一种有效的口服活性蛋白磷酸酶抑制剂。微囊藻毒素RR诱导小鼠肝细胞凋亡和内质网应激[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 代谢疾病

[体内研究]

微囊藻毒素RR(0、4..6、23、46、93、186µg/mL灌胃；每日一次,连续 7.天) 在小鼠肝脏中以剂量依赖性方式诱导细胞凋亡并增加 Bax、p53的表达,降低 Bcl-2的表达[2]。动物模型：20-22 g,雄性ICR小鼠[2]剂量：0、4、6、23、46、93、186µg/mL给药：给药；结果：0、4、6、23、46、93、186µg/mL的小鼠肝细胞凋亡率分别为10.46、12.6、12.7、13.3、28.5和37.5%；在小鼠肝脏中Bax、p53的表达增加,Bcl-2的表达以剂量依赖的方式减少。

[参考文献]

[1]. Matsushima R, et al. In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts. Biochem Biophys Res Commun. 1990 Sep 14;171(2):867-74.

[2]. Huang P, et al. The apoptotic effect of oral administration of microcystin-RR on mice liver. Environ Toxicol. 2011 Oct;26(5):443-52.

微囊藻毒素RR物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C₄₉H₇₅N₁₃O₁₂

[ 分子量 ]:
1038.200

[ 闪点 ]:
11 °C

[ 精确质量 ]:
1037.565796

[ PSA ]:
402.54000

[ LogP ]:
-3.96

[ 外观性状 ]:
发白的薄膜

[ 折射率 ]:
1.619

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
ethanol: water (1:1): 50 mg/mL

微囊藻毒素RRMSDS

详细MSDS(安全技术说明书)

微囊藻毒素RR安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H315-H317-H319-H330-H335

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;T+: Very toxic;F: Flammable;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
26-36/37/39-45-36/37-16

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

微囊藻毒素RR文献

The conjugation of microcystin-RR by human recombinant GSTs and hepatic cytosol.

Toxicol. Lett. 219(3) , 231-8, (2013)

Many cyanobacterial species can produce cyanotoxins, among which mycrocistins (MC) are a group of ≈100 congeners of hepatotoxic cyclic heptapeptides. MC-RR differs from MC-LR, the most studied congene...

Similar uptake profiles of microcystin-LR and -RR in an in vitro human intestinal model.

Toxicology 290(1) , 7-13, (2011)

Microcystins (MCs) are cyclic hepatotoxins produced by various species of cyanobacteria. Their structure includes two variable amino acids (AA) leading to more than 80 MC variants. In this study, we f...

In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis.

Food Chem. Toxicol. 49(7) , 1560-4, (2011)

Blue-green algae (BGA) have been consumed as food and herbal medicine for centuries. However, safety for their consumption has not been well investigated. This study was undertaken to evaluate in vitr...

更多文献