花生四烯酸

花生四烯酸用途

Eicosatetraynoic acid (ETYA) 是 cyclooxygenase 和 lipoxygenase 的非特异性抑制剂 (ID50=8 μM 和 4 μM)。Eicosatetraynoic acid (ETYA) 10 μM 激活 PPARα 和 PPARγ 嵌合体。

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花生四烯酸名称

[ CAS 号 ]:
1191-85-1

[ 中文名 ]:
5,8,11,14-花生四烯酸

[ 英文名 ]:
5,8,11,14-Icosatetraynoic acid

[中文别名 ]:

花生四烯酸

[英文别名 ]:

Eicosa-5,8,11,14-tetrainsaeure
MFCD00036967
5,8,11,14-eicosatetrayonic acid
5,8,11,14-Icosatetraynoic acid
5,8,11,14-Eicosatetraynoic acid
ETYA
Icosa-5,8,11,14-tetraynoic acid
Octadehydroarachidonic acid
eicosatetraynoic acid

花生四烯酸生物活性

[ 描述 ]:

Eicosatetraynoic acid (ETYA) 是 cyclooxygenase 和 lipoxygenase 的非特异性抑制剂 (ID50=8 μM 和 4 μM)。Eicosatetraynoic acid (ETYA) 10 μM 激活 PPARα 和 PPARγ 嵌合体。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 细胞周期/DNA损伤 >> PPAR

信号通路 >> 免疫及炎症 >> COX

[ 靶点 ]

COX:8 μM (ID50)

[参考文献]

[1]. Hammarström S, et al. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta. 1977 Jun 22;487(3):517-9.

[2]. Kliewer SA, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.

花生四烯酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
490.3±45.0 °C at 760 mmHg

[ 熔点 ]:
79-81ºC

[ 分子式 ]:
C₂₀H₂₄O₂

[ 分子量 ]:
296.403

[ 闪点 ]:
226.6±23.4 °C

[ 精确质量 ]:
296.177643

[ PSA ]:
37.30000

[ LogP ]:
5.19

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
2-8°C，密封，干燥

花生四烯酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2916190090

花生四烯酸合成路线

详细合成路线

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花生四烯酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

花生四烯酸文献

Arachidonic acid induces brain endothelial cell apoptosis via p38-MAPK and intracellular calcium signaling.

Microvasc. Res. 98 , 145-58, (2015)

Arachidonic acid (AA), a bioactive fatty acid whose levels increase during neuroinflammation, contributes to cerebral vascular damage and dysfunction. However, the mode of injury and underlying signal...

High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.

PLoS ONE 6(4) , e19158, (2011)

Elevation of extracellular Ca(2+) concentration induces intracellular Ca(2+) signaling in parathyroid cells. The response is due to stimulation of the phospholipase C/Ca(2+) pathways, but the direct m...

Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels.

Am. J. Physiol. Heart Circ. Physiol. 285(6) , H2309-15, (2003)

Reactive oxygen species (ROS) have been proposed to mediate vasodilation in the microcirculation. We investigated the role of ROS in arachidonic acid (AA)-induced coronary microvascular dilation. Porc...

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