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FPL 64176

FPL 64176用途

FPL64176是一种非二氢吡啶化合物,是L型钙通道的有效激动剂,EC50值为16 nM[1][2]。

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FPL 64176名称

[ CAS 号 ]:
120934-96-5

[ 中文名 ]:
2,5-二甲基-4-[2-(苯基甲基)苯甲酰]-1H-吡咯-3-羧酸甲酯

[ 英文名 ]:
FPL64176

[英文别名 ]:

MFCD00274043

FPL 64176生物活性

[ 描述 ]:

FPL64176是一种非二氢吡啶化合物,是L型钙通道的有效激动剂,EC50值为16 nM[1][2]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 心血管疾病

[参考文献]

[1]. Zheng W, Rampe D, Triggle DJ. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol Pharmacol. 1991 Nov;40(5):734-41.

[2]. Baxter AJ, Dixon J, Ince F, Manners CN, Teague SJ. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J Med Chem.

FPL 64176物理化学性质

[ 密度 ]:
1.174g/cm3

[ 沸点 ]:
547.8ºC at 760mmHg

[ 熔点 ]:
144 - 145 °C

[ 分子式 ]:
C₂₂H₂₁NO₃

[ 分子量 ]:
347.40700

[ 闪点 ]:
285.1ºC

[ 精确质量 ]:
347.15200

[ PSA ]:
59.16000

[ LogP ]:
4.23990

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
4.72E-12mmHg at 25°C

[ 折射率 ]:
1.6

[ 储存条件 ]:
2-8°C

FPL 64176MSDS

FPL 64176安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

FPL 64176合成路线

FPL 64176上下游产品

FPL 64176上游产品

FPL 64176下游产品

FPL 64176文献

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A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria.

Eur. J. Pharmacol. 576(1-3) , 122-31, (2007)

Few experimental models produce spontaneous tachycardia in normal left atria to allow the study of the cellular mechanisms underlying this contributor to atrial fibrillation. We reported 2-aminoethoxy...

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Brain Res. 1276 , 159-70, (2009)

Estrogen-mediated neuroprotection is observed in neurodegenerative disease and neurotrauma models; however, determining a mechanism for these effects has been difficult. We propose that estrogen may l...

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