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2-氨基-5-硝基噻唑

2-氨基-5-硝基噻唑用途

【用途一】
用作制备偶氮杂环染料的重要中间体

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2-氨基-5-硝基噻唑名称

[ CAS 号 ]:
121-66-4

[ 中文名 ]:
2-氨基-5-硝基噻唑

[ 英文名 ]:
5-Nitrothiazol-2-amine

[中文别名 ]:

[英文别名 ]:

2-Amino-5-nitrothiazole
2-Thiazolamine, 5-nitro-
5-nitro-2-thiazolylamin
5-Nitrothiazol-2-amine
5-Nitro-1,3-thiazol-2-amine
MFCD00005326
EINECS 204-490-9
2-AMINO-5-NITRO THIAZOLE

2-氨基-5-硝基噻唑物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
345.1±15.0 °C at 760 mmHg

[ 熔点 ]:
195-200 °C (dec.)(lit.)

[ 分子式 ]:
C₃H₃N₃O₂S

[ 分子量 ]:
145.140

[ 闪点 ]:
162.5±20.4 °C

[ 精确质量 ]:
144.994598

[ PSA ]:
112.97000

[ LogP ]:
0.83

[ 外观性状 ]:
绿色黄色,至橙色或棕色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.705

[ 储存条件 ]:
库房通风低温干燥,与硫酸和硝酸分开存放

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides.

[ 水溶解性 ]:
<0.1 g/100 mL at 20 ºC

2-氨基-5-硝基噻唑MSDS

2-氨基-5-硝基噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ2800000

CHEMICAL NAME :: Thiazole, 2-amino-5-nitro-

CAS REGISTRY NUMBER :: 121-66-4

BEILSTEIN REFERENCE NO. :: 0126797

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C3-H3-N3-O2-S

MOLECULAR WEIGHT :: 145.15

WISWESSER LINE NOTATION :: T5N CSJ BZ DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 gm/kg/46W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 700 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 15600 ug/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),103,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,71,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,71,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

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2-氨基-5-硝基噻唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R40

[ 安全声明 (欧洲) ]:
S26-S45-S24/25

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
XJ2800000

[ 海关编码 ]:
2934100090

2-氨基-5-硝基噻唑合成路线

2-氨基-5-硝基噻唑上下游产品

2-氨基-5-硝基噻唑上游产品

2-氨基-5-硝基噻唑下游产品

2-氨基-5-硝基噻唑制备

以氯乙醛为原料，与硫脲进行反应制得２-氨基噻唑（Ⅰ），再经硝化成２-氨基-５-硝基噻唑（Ⅱ）。

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2-氨基-5-硝基噻唑海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

2-氨基-5-硝基噻唑文献

Evaluation of 2-amino-5-nitrothiazole as a hypoxic cell radiosensitizer.

Radiat. Res. 90(3) , 575-85, (1982)

Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro.

Radiat. Res. 112(2) , 273-82, (1987)

Complexes of general formula [PtCl2(NH3)L] with one radiosensitizing ligand per platinum are compared with ligand L alone, complexes with two radiosensitizers per platinum [PtCl2L2], and their analogs...

2-amino-5-nitrothiazole.

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 31 , 71-7, (1983)

更多文献

2-氨基-5-硝基噻唑

2-氨基-5-硝基噻唑用途

2-氨基-5-硝基噻唑名称

2-氨基-5-硝基噻唑物理化学性质

2-氨基-5-硝基噻唑MSDS

详细MSDS(安全技术说明书)

2-氨基-5-硝基噻唑毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2-氨基-5-硝基噻唑安全信息

2-氨基-5-硝基噻唑合成路线

详细合成路线

2-氨基-5-硝基噻唑上下游产品

2-氨基-5-硝基噻唑上游产品

2-氨基-5-硝基噻唑下游产品

2-氨基-5-硝基噻唑制备

2-氨基-5-硝基噻唑海关

2-氨基-5-硝基噻唑文献

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