< 生产厂家 价格 >

2-氨基噻唑

2-氨基噻唑用途

Aminothiazole (2-Aminothiazole)是合成多种活性化合物的元件,包括抗生素,染料等,特别是作为朊病毒抑制剂合成母体化合物。
点击显示

2-氨基噻唑名称

[ CAS 号 ]:
96-50-4

[ 中文名 ]:
2-氨基噻唑

[ 英文名 ]:
2-Aminothiazole

[中文别名 ]:

[英文别名 ]:

2-氨基噻唑生物活性

[ 描述 ]:

Aminothiazole (2-Aminothiazole)是合成多种活性化合物的元件,包括抗生素,染料等,特别是作为朊病毒抑制剂合成母体化合物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 其他

[参考文献]

[1]. Gallardo-Godoy A, et al. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24;54(4):1010-21.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

2-氨基噻唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
216.4±9.0 °C at 760 mmHg

[ 熔点 ]:
91-93 °C(lit.)

[ 分子式 ]:
C3H4N2S

[ 分子量 ]:
100.142

[ 闪点 ]:
84.7±18.7 °C

[ 精确质量 ]:
100.009521

[ PSA ]:
67.15000

[ LogP ]:
0.38

[ 外观性状 ]:
淡棕色晶体或棕色粒状的固体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.645

[ 储存条件 ]:
库房通风低温干燥,与硝酸,硫酸分开存放

[ 水溶解性 ]:
100 g/L (20 ºC)

2-氨基噻唑MSDS

详细MSDS(安全技术说明书)

2-氨基噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ2100000
CHEMICAL NAME :
Thiazole, 2-amino-
CAS REGISTRY NUMBER :
96-50-4
LAST UPDATED :
199806
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C3-H4-N2-S
MOLECULAR WEIGHT :
100.15
WISWESSER LINE NOTATION :
T5N CSJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4500 mg/kg/56D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/m3/7H/61D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - dyspnea Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
200 mg/m3/7H/30D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
25 mg/m3/7H/62D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
557 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 155,17,1985
点击显示

2-氨基噻唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37

[ 安全声明 (欧洲) ]:
S26-S36/37-S39

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
XJ2100000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
2934999090

2-氨基噻唑合成路线

详细合成路线

2-氨基噻唑上下游产品

2-氨基噻唑上游产品

2-氨基噻唑下游产品

2-氨基噻唑制备

由硫脲与氯乙醛（或乙醇和氯气，或α,β二氯乙基乙醚）经环合而得。在反应器中加入热水、硫脲和α,β-二氯乙基乙醚。在搅拌下回流2h。冷却，经滴液漏斗加入氢氧化钠溶液，使溶液呈碱性，析出2-氨基噻唑晶体。然后加入乙醚使之溶解。分出醚层，用水洗涤后，以无水硫酸钠干燥，蒸出乙醚得粗品。用乙醇重结晶，得黄色晶体。产率为80%，熔点90℃。
点击显示

2-氨基噻唑海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

2-氨基噻唑文献

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

Bioorg. Med. Chem. 16 , 6193-206, (2008)

Selective inhibitors of neuronal nitric oxide synthase (nNOS) were shown to protect brain and may be useful in the treatment of neurodegenerative diseases. In this context, our purpose has been to des...

Effects of L-arginine, mirabegron, and oxybutynin on the primary bladder afferent nerve activities synchronized with reflexic, rhythmic bladder contractions in the rat.

Neurourol. Urodyn. 34(4) , 368-74, (2015)

We measured single-unit mechanosensitive afferent activities (SAAs) during reflexic, rhythmic bladder contractions (RBCs), and examined whether L-arginine, an NO substrate, and mirabegron, a β3-adreno...


更多文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：2-氨基噻唑

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥98.0/100g ￥308.0/500g

联系人：刘佳

产品详情：2-氨基噻唑

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥469.0/5g ￥489.0/1g ￥749.0/10g ￥需询单/1g

联系人：李先生

产品详情：Aminothiazole

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥38.0/25g ￥77.0/100g ￥233.0/500g ￥1057.0/2500g

联系人：夏言

产品详情：[Perfemiker]2-氨基噻唑,97%

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥73.9/100g ￥29.9/25g ￥172.9/500g ￥688.9/3kg

联系人：阿拉丁

产品详情：2-氨基噻唑

查看所有供应商请点击：

2-氨基噻唑供应商

相关化合物

【2-氨基噻唑】化源网提供2-氨基噻唑CAS号96-50-4，2-氨基噻唑MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询2-氨基噻唑上化源网，专业又轻松。>>电脑版：2-氨基噻唑

标题：2-氨基噻唑_MSDS_用途_密度_2-氨基噻唑CAS号【96-50-4】_化源网 地址：https://m.chemsrc.com/mip/cas/96-50-4_951973.html