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硝唑尼特

硝唑尼特用途

Nitazoxanide是抗原生动物化合物,对犬流感病毒的IC50为0.17 到 0.21μM。

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硝唑尼特名称

[ CAS 号 ]:
55981-09-4

[ 中文名 ]:
硝唑尼特

[ 英文名 ]:
Nitazoxanide

[中文别名 ]:

硝唑克酰胺

[英文别名 ]:

Cryptaz
Heliton
Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-
Alinia
o-(N-(5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate
Nitazoxanida
[14C]-Nitazoxanide
EINECS 259-931-8
Colufase
2-(2-Acetoxy)benzamido-5-nitrothiazole

硝唑尼特生物活性

[ 描述 ]:

Nitazoxanide是抗原生动物化合物,对犬流感病毒的IC50为0.17 到 0.21μM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 感染

[参考文献]

[1]. Rossignol JF, et al. Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level. J Biol Chem. 2009 Oct 23;284(43):29798-808.

[2]. Somvanshi VS, et al. Nitazoxanide: Nematicidal mode of action and drug combination studies. Mol Biochem Parasitol. 2014 Jan 8;193(1):1-8.

[相关活性小分子]

硝唑尼特物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 熔点 ]:
202ºC

[ 分子式 ]:
C₁₂H₉N₃O₅S

[ 分子量 ]:
307.282

[ 精确质量 ]:
307.026276

[ PSA ]:
142.35000

[ LogP ]:
1.79

[ 外观性状 ]:
淡黄色至白色结晶粉末

[ 折射率 ]:
1.673

[ 储存条件 ]:
-20°C Freezer

硝唑尼特MSDS

硝唑尼特毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN7830000

CHEMICAL NAME :: Salicylamide, N-(5-nitro-2-thiazolyl)-, acetate (ester)

CAS REGISTRY NUMBER :: 55981-09-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C12-H9-N3-O5-S

MOLECULAR WEIGHT :: 307.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,49,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,49,1985

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic)

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,49,1985

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,49,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44100 mg/kg/14W-C

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands Liver - changes in liver weight Endocrine - changes in spleen weight

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,49,1985

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硝唑尼特安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2942000000

硝唑尼特合成路线

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硝唑尼特上游产品

硝唑尼特下游产品

硝唑尼特海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

硝唑尼特文献

Validated stability indicating RP-HPLC for quantitation of nitazoxanide in presence of its alkaline degradation products and their characterization by HPLC-tandem mass spectrometry.

J. Chromatogr. Sci. 52(9) , 1071-81, (2014)

A simple and sensitive stability indicating HPLC method was developed and validated for quantitative determination of Nitazoxanide (NTZ), a new antiprotozoal drug, in presence of degradation products ...

Metabolism of nitazoxanide in rats, pigs, and chickens: Application of liquid chromatography coupled to hybrid linear ion trap/Orbitrap mass spectrometer.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 147-54, (2015)

Nitazoxanide (NTZ) is a nitrothiazole benzamide compound with a broad activity spectrum against parasites, Gram-positive and Gram-negative anaerobic bacteria, and viruses. In this study, hybrid linear...

Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.

Parasit. Vectors 8 , 332, (2015)

In the local Malaysian context, herbal plants such as Eurycoma longifolia (Tongkat Ali), Orthosiphon stamineus (MisaiKucing), Ficus deltoidea (Mas Cotek), Zingiber officinale (Halia Bara) and Barringt...

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