3,3′,5-三碘-L-甲状腺素-13C6

3,3′,5-三碘-L-甲状腺素-13C6用途

Liothyronie-13C6-1是13C标记的Liothyroine。Liothyronine是一种有效的甲状腺激素受体TRα和TRβ激动剂,hTRα和hTRβ的Kis分别为2.33 nM[1][2]。

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3,3′,5-三碘-L-甲状腺素-13C6名称

[ CAS 号 ]:
1213431-76-5

[ 中文名 ]:
3,3′,5-三碘-L-甲状腺素-13C6

[ 英文名 ]:
Liothyronine-13C6-1

3,3′,5-三碘-L-甲状腺素-13C6生物活性

[ 描述 ]:

Liothyronie-13C6-1是13C标记的Liothyroine。Liothyronine是一种有效的甲状腺激素受体TRα和TRβ激动剂,hTRα和hTRβ的Kis分别为2.33 nM[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 内分泌

信号通路 >> 其他 >> 甲状腺激素受体

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

3,3′,5-三碘-L-甲状腺素-13C6物理化学性质

[ 分子式 ]:
₁₃C₆C₉H₁₂I₃NO₄

[ 分子量 ]:
656.93

[ 外观性状 ]:
liquid

3,3′,5-三碘-L-甲状腺素-13C6安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

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