盐酸昂丹司琼-d6
盐酸昂丹司琼-d6用途
昂丹司琼-6(盐酸)是氘标记的盐酸昂丹司酮[1]。盐酸昂丹司琼是一种5-羟色胺5-HT3受体拮抗剂,主要用作止吐剂(治疗恶心和呕吐),通常在化疗后使用[2][3][4][5][6][7]。
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盐酸昂丹司琼-d6名称
盐酸昂丹司琼-d6生物活性
[ 描述 ]:
昂丹司琼-6(盐酸)是氘标记的盐酸昂丹司酮[1]。盐酸昂丹司琼是一种5-羟色胺5-HT3受体拮抗剂,主要用作止吐剂(治疗恶心和呕吐),通常在化疗后使用[2][3][4][5][6][7]。
[ 相关类别 ]:
[体外研究]
氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
[参考文献]
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[2]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.
[3]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep362(3):255-65.
[4]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 11300:41-50.
[5]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov20(6):1103-16.
[6]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb20(1):78-83.
[7]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May12(3):421-31.
盐酸昂丹司琼-d6物理化学性质
[ 分子式 ]:
C18H14D6ClN3O
[ 分子量 ]:
335.86
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【盐酸昂丹司琼-d6】化源网提供盐酸昂丹司琼-d6CAS号1225442-22-7，盐酸昂丹司琼-d6MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询盐酸昂丹司琼-d6上化源网，专业又轻松。>>电脑版：盐酸昂丹司琼-d6
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