丁二酸二乙酯

Diethyl succinate (Diethyl Butanedioate) 可在生理 pH 下使用并穿过生物膜,掺入组织培养物中的细胞中,通过 TCA 循环进行代谢。Diethyl succinate 无毒性,可用于香料和调味剂中。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
218.4±8.0 °C at 760 mmHg

[ 熔点 ]:
-20 °C

[ 分子式 ]:
C₈H₁₄O₄

[ 分子量 ]:
174.194

[ 闪点 ]:
90.6±0.0 °C

[ 精确质量 ]:
174.089203

[ PSA ]:
52.60000

[ LogP ]:
1.26

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
6 (vs air)

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.423

[ 储存条件 ]:
室温

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

WM7400000

CHEMICAL NAME :

Succinic acid, diethyl ester

CAS REGISTRY NUMBER :

123-25-1

BEILSTEIN REFERENCE NO. :

0907645

LAST UPDATED :

199806

DATA ITEMS CITED :

6

MOLECULAR FORMULA :

C8-H14-O4

MOLECULAR WEIGHT :

174.22

WISWESSER LINE NOTATION :

2OV2VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,707,1978

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rat

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,707,1978

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,374,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8530 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3671 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WM7400000

[ 海关编码 ]:
29171990

详细合成路线

丁二酸二乙酯上游产品

丁二酸二乙酯下游产品

1. 由乙醇和丁二酸发生酰化制备；或由乙醇和丁二酸在浓硫酸存在下，在苯溶液中直接酯化制取。

2.制法：

于装有蒸馏装置的反应瓶中，加入丁二酸（2）58g（0.5mol），无水乙醇82g（1.76mol），用金属钠干燥的苯180mL，一粒沸石，11mL硫酸。加热回流反应8h。将反应物倒入过量的水中，分出有机层，水层用苯提取两次。合并有机层，少量水洗涤，再用饱和碳酸钠溶液洗涤。无水硫酸钠干燥。减压分馏，收集80～83℃/400Pa的馏分，得丁二酸二乙酯（1）75g，收率85%。

[ 海关编码 ]: 29171990

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